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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00581


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00581
General rule information [?]

Accession PRU00581
Dates 17-OCT-2006 (Created)
30-SEP-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51225; MARVEL
Name MARVEL domain
Function The ~130-residue MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families.
Scope(s) Eukaryota
Metazoa
Example(s) Q8IZ96;

Propagated annotation [?]

Keywords [?]

Membrane
Transmembrane

Gene Ontology [?]

GO:0016020; Cellular component:membrane

Cross-references [?]

General Transmembrane; -; 4;

Features [?]

From: PS51225
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MARVEL #"

Additional information [?]

Size range 115-215 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]