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annotation rule: PRU00584

General rule information [?]

Accession PRU00584
Dates 19-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51255; ADPK
Name ADP-dependent kinase (ADPK) domain
Function Archeal ADP-dependent glucokinases (ADPGKs) and phosphofructokinases (ADPPKKs) form an ADP-dependent kinase (ADPK) family, which was tentatively named the PFKC family. A ~460-residue ADPK domain is also found in a bifunctional ADP-dependent gluco/phosphofructo-kinase (ADP-GK/PFK) from Methanococcus jannaschii as well as in homologous hypothetical proteins present in several eukaryotes.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.7.1.-;

Comments [?]

case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case

Pathway Carbohydrate degradation; glycolysis.

Gene Ontology [?]

GO:0006096; Biological process: glycolytic process.
GO:0016301; Molecular function: kinase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case

GO:0016740; Molecular function: transferase activity.

Keywords [?]

case <FTGroup:1>
end case


Features [?]

From: PS51255
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ADPK #        
ACT_SITE     446     446       Proton acceptor     D  
METAL     267     267       Magnesium     E   1
METAL     297     297       Magnesium     E   1
METAL     446     446       Magnesium     D   1

Additional information [?]

Size range 440-485 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9BRR6 (ADPGK_HUMAN)
Scope
Eukaryota
Archaea

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]