ProRule PRU00584
General rule information
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| Accession | PRU00584 |
| Dates | 19-JAN-2007 (Created)
19-NOV-2022 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51255; ADPK |
Name | ADP-dependent kinase (ADPK) domain |
| Function | Archeal ADP-dependent glucokinases (ADPGKs) and phosphofructokinases (ADPPKKs) form an ADP-dependent kinase (ADPK) family, which was tentatively named the PFKC family. A ~460-residue ADPK domain is also found in a bifunctional ADP-dependent gluco/phosphofructo-kinase (ADP-GK/PFK) from Methanococcus jannaschii as well as in homologous hypothetical proteins present in several eukaryotes. |
| Scope(s) |
Eukaryota Archaea |
| Example(s) | Q9BRR6 (ADPGK_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.7.1.-; |
Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| PATHWAY | Carbohydrate degradation; glycolysis. |
Keywords
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| Glycolysis | |
| Kinase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Transferase | |
Gene Ontology
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| GO:0006096; Biological process:glycolytic process | |
| GO:0016301; Molecular function:kinase activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0016740; Molecular function:transferase activity | |
Features
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| From: PS51255 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ADPK #" | |||||||||
| ACT_SITE | 446 | 446 | /note="Proton acceptor" | D | ||||||||
| BINDING | 267 | 267 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 297 | 297 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 446 | 446 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
Additional information
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| Size range | 440-485 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [14] Eukaryota [4] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain