PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00584


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00584
General rule information [?]

Accession PRU00584
Dates 19-JAN-2007 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51255; ADPK
Name ADP-dependent kinase (ADPK) domain
Function Archeal ADP-dependent glucokinases (ADPGKs) and phosphofructokinases (ADPPKKs) form an ADP-dependent kinase (ADPK) family, which was tentatively named the PFKC family. A ~460-residue ADPK domain is also found in a bifunctional ADP-dependent gluco/phosphofructo-kinase (ADP-GK/PFK) from Methanococcus jannaschii as well as in homologous hypothetical proteins present in several eukaryotes.
Scope(s) Eukaryota
Archaea
Example(s) Q9BRR6;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.7.1.-;

Comments [?]

case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
PATHWAYCarbohydrate degradation; glycolysis.

Keywords [?]

Glycolysis
Kinase
case <FTGroup:1>
Magnesium
Metal-binding
end case
Transferase

Gene Ontology [?]

GO:0006096; Biological process:glycolytic process
GO:0016301; Molecular function:kinase activity
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016740; Molecular function:transferase activity

Features [?]

From: PS51255
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ADPK #"
ACT_SITE 446 446 /note="Proton acceptor" D
BINDING 267 267 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 E 1
BINDING 297 297 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 E 1
BINDING 446 446 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 D 1

Additional information [?]

Size range 440-485 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]