ProRule PRU00584

General rule information [?]

Accession PRU00584
Dates 19-JAN-2007 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51255; ADPK
Name ADP-dependent kinase (ADPK) domain
Function Archeal ADP-dependent glucokinases (ADPGKs) and phosphofructokinases (ADPPKKs) form an ADP-dependent kinase (ADPK) family, which was tentatively named the PFKC family. A ~460-residue ADPK domain is also found in a bifunctional ADP-dependent gluco/phosphofructo-kinase (ADP-GK/PFK) from Methanococcus jannaschii as well as in homologous hypothetical proteins present in several eukaryotes.
Scope(s) Eukaryota
Example(s) Q9BRR6 (ADPGK_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.7.1.-;

Comments [?]

case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
end case
PATHWAYCarbohydrate degradation; glycolysis.

Keywords [?]

Gene Ontology [?]

GO:0006096; Biological process:glycolytic process
GO:0016301; Molecular function:kinase activity
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016740; Molecular function:transferase activity

Features [?]

From: PS51255
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ADPK #"
ACT_SITE 446 446 /note="Proton acceptor" D
BINDING 267 267 /ligand="Mg(2+)"
E 1
BINDING 297 297 /ligand="Mg(2+)"
E 1
BINDING 446 446 /ligand="Mg(2+)"
D 1

Additional information [?]

Size range 440-485 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]