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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00611


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00611
General rule information [?]

Accession PRU00611
Dates 19-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51281; TAP_C
Name TAP C-terminal (TAP-C) domain
Function Members of the NXF family of shuttling transport receptors for nuclear export of mRNA have a modular structure. Their most C-terminal TAP-C domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling.
Scope(s) Eukaryota
Example(s) P84149;

Propagated annotation [?]

Comments [?]

FUNCTIONInvolved in the export of mRNA from the nucleus to the cytoplasm.
SUBCELLULAR LOCATIONNucleus. Cytoplasm. Note=Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.

Keywords [?]

Cytoplasm
mRNA transport
Nucleus
Transport

Gene Ontology [?]

GO:0006397; Biological process:mRNA processing
GO:0006406; Biological process:mRNA export from nucleus
GO:0005634; Cellular component:nucleus
GO:0006810; Biological process:transport

Features [?]

From: PS51281
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TAP-C #"

Additional information [?]

Size range 50-60 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]