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annotation rule: PRU00618

General rule information [?]

Accession PRU00618
Dates 8-JUN-2020 (Created)
8-JUN-2020 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51285; AGC_KINASE_CTER
Name AGC-kinase C-terminal domain
Function AGC kinase proteins are characterized by three conserved phosphorylation sites that critically regulate their function. The first one is located in an activation loop in the center of the kinase domain. The two other phosphorylation sites are located outside the kinase domain in a conserved region on its C-terminal side, the AGC-kinase C-terminal domain. These sites serves as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive.

Propagated annotation [?]


Keywords [?]

case <FTTag:phospho>
end case


Features [?]

From: PS51285
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       AGC-kinase C-terminal        
MOD_RES     42     42       Phosphoserine   phospho   S  
MOD_RES     42     42       Phosphothreonine   phospho   T  
MOD_RES     61     61       Phosphoserine   phospho   S  
MOD_RES     61     61       Phosphothreonine   phospho   T  
MOD_RES     62     62       Phosphotyrosine   phospho   Y  

Additional information [?]

Size range 40-125 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6P0Q8 (MAST2_HUMAN)
Scope
Eukaryota
Viruses; Murine leukemia virus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]