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ProRule PRU00618


General rule information [?]

Accession PRU00618
Dates 8-JUN-2020 (Created)
8-JUN-2020 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51285; AGC_KINASE_CTER
Name AGC-kinase C-terminal domain
Function AGC kinase proteins are characterized by three conserved phosphorylation sites that critically regulate their function. The first one is located in an activation loop in the center of the kinase domain. The two other phosphorylation sites are located outside the kinase domain in a conserved region on its C-terminal side, the AGC-kinase C-terminal domain. These sites serves as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive.
Scope(s) Eukaryota
Viruses
Murine leukemia virus
Example(s) Q6P0Q8 (MAST2_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTTag:phospho>
Phosphoprotein
end case

Features [?]

From: PS51285
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="AGC-kinase C-terminal"
MOD_RES 42 42 /note="Phosphoserine" phospho S
MOD_RES 42 42 /note="Phosphothreonine" phospho T
MOD_RES 61 61 /note="Phosphoserine" phospho S
MOD_RES 61 61 /note="Phosphothreonine" phospho T
MOD_RES 62 62 /note="Phosphotyrosine" phospho Y

Additional information [?]

Size range 40-125 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]