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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00625


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00625
General rule information [?]

Accession PRU00625
Dates 23-FEB-2007 (Created)
27-JUN-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51294; HTH_MYB
Name Myb-type HTH DNA-binding domain
Function The myb-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of ~55 amino acids, typically occurring in a tandem repeat in eukaryotic transcription factors. Some single myb-like domains can be involved in other functions, such as protein-binding, but several single myb-like domains bind DNA (see ).
Scope(s) Eukaryota
Viruses
Alpharetrovirus
Example(s) P54274; O49397;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription
GO:0005634; Cellular component:nucleus

Features [?]

From: PS51294
Key From To Description Tag Condition FTGroup
case <Feature:PS51294:44-52=R-x-N-V-A-S-H-L-Q>
DNA_BIND entry exit /note="Myb-like GARP #"
else
DOMAIN entry exit /note="HTH myb-type #"
DNA_BIND 30 55 /note="H-T-H motif"
end case

Additional information [?]

Size range 40-80 amino acids
Related rules PRU00133
PRU00624
Fusion None
Repeats 1-5
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]