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annotation rule: PRU00625

General rule information [?]

Accession PRU00625
Dates 23-FEB-2007 (Created)
27-JUN-2022 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51294; HTH_MYB
Names Myb-type HTH DNA-binding domain; Myb/SANT repeat
Function The myb-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of ~55 amino acids, typically occurring in a tandem repeat in eukaryotic transcription factors. Some single myb-like domains can be involved in other functions, such as protein-binding, but several single myb-like domains bind DNA (see ).

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.
GO:0005634; Cellular component: nucleus.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation

Features [?]

case <Feature:PS51294:44-52=R-x-N-V-A-S-H-L-Q>
From: PS51294
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     entry     exit       Myb-like GARP #        
else
DOMAIN     entry     exit       HTH myb-type #        
DNA_BIND     30     55       H-T-H motif        
end case


Additional information [?]

Size range 40-80 amino acids
Related rules PRU00133; PRU00624
Repeats 1-5
Topology Undefined
Examples P54274 (TERF1_HUMAN); O49397 (ARR10_ARATH): [Recover all]
Scope
Eukaryota
Viruses; Alpharetrovirus

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]