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ProRule PRU00654


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PURL: https://purl.expasy.org/prosite/rule/PRU00654
General rule information [?]

Accession PRU00654
Dates 09-APR-2009 (Created)
03-SEP-2024 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS51324; ERV_ALR
Name ERV/ALR sulfhydryl oxidase domain
Function The ~100-residue ERV/ALR sulfhydryl oxidase domain is a versatile module adapted for catalysis of disulfide bond formation in various organelles and biological settings.
Scope(s) Eukaryota
Viruses
Example(s) P55789 (ALR_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FT:2>
Protein name AltName: Full=FAD-linked sulfhydryl oxidase;
                 EC=1.8.3.2;

Comments [?]

FUNCTIONFAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.
CATALYTIC ACTIVITY Reaction=2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;

Keywords [?]

FAD
Flavoprotein
Oxidoreductase
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity
GO:0016972; Molecular function:thiol oxidase activity

Features [?]

From: PS51324
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ERV/ALR sulfhydryl oxidase #"
DISULFID 48 51 /note="Redox-active" disulf C-x*-C
DISULFID 78 95 disulf C-x*-C

Additional information [?]

Size range 84-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]