We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00654
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00654
General rule information
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| Accession | PRU00654 |
| Dates | 09-APR-2009 (Created)
03-SEP-2024 (Last updated, Version 16) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51324; ERV_ALR |
Name | ERV/ALR sulfhydryl oxidase domain |
| Function | The ~100-residue ERV/ALR sulfhydryl oxidase domain is a versatile module adapted for catalysis of disulfide bond formation in various organelles and biological settings. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | P55789; |
Propagated annotation
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Identifier, protein and gene names
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| case <FT:2> | |
| Protein name | AltName: Full=FAD-linked sulfhydryl oxidase; EC=1.8.3.2; |
Comments
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| FUNCTION | FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. |
| CATALYTIC ACTIVITY | Reaction=2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2; Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
Keywords
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| FAD | |
| Flavoprotein | |
| Oxidoreductase | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0016972; Molecular function:thiol oxidase activity |
Features
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| From: PS51324 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ERV/ALR sulfhydryl oxidase #" | |||||||||
| DISULFID | 48 | 51 | /note="Redox-active" | disulf | C-x*-C | |||||||
| DISULFID | 78 | 95 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 84-120 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [21] Viruses [15] All [ 36 ]
- Retrieve set of proteins with 3D structure for this domain