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annotation rule: PRU00654

General rule information [?]

Accession PRU00654
Dates 9-APR-2009 (Created)
11-JAN-2021 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS51324; ERV_ALR
Name ERV/ALR sulfhydryl oxidase domain
Function The ~100-residue ERV/ALR sulfhydryl oxidase domain is a versatile module adapted for catalysis of disulfide bond formation in various organelles and biological settings.

Propagated annotation [?]


Description [?]

case <FT:2>
AltName: Full=FAD-linked sulfhydryl oxidase; EC 1.8.3.2;

Comments [?]

Function FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.
Catalytic activity RHEA:17357: O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'
EC 1.8.3.2
Cofactor Note: FAD.

Gene Ontology [?]

GO:0016491; Molecular function: oxidoreductase activity.
GO:0016972; Molecular function: thiol oxidase activity.

Keywords [?]

FAD
Flavoprotein
Oxidoreductase
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS51324
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ERV/ALR sulfhydryl oxidase #        
DISULFID     48     51       Redox-active   disulf   C-x*-C  
DISULFID     78     95           disulf   C-x*-C  

Additional information [?]

Size range 84-120 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P55789 (ALR_HUMAN)
Scope
Eukaryota
Viruses
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]