PRU00661
General rule information
[?]
Accession | PRU00661 |
Dates | 14-APR-2009 (Created) 21-NOV-2019 (Last updated, Version 14) |
Data class | Domain |
Predictors | PROSITE; PS51331; THYX |
Name | Flavin-dependent thymidylate synthase (thyX) domain |
Function | The thyx domain contains FAD and methylates dUMP at position 5 of the pyrimidine ring. |
Propagated annotation
[?]
Description
[?]
case not <Triggered>
AltName: Full=Probable thymidylate synthase; Short=TS; Short=TSase; EC 2.1.1.148; |
end case
Comments
[?]
Function | Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. |
Catalytic activity | RHEA:29043: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
EC 2.1.1.148 |
Cofactor | FAD synthase) domain |
Gene Ontology
[?]
GO:0008168; Molecular function: methyltransferase activity.
GO:0016740; Molecular function: transferase activity.
GO:0050797; Molecular function: thymidylate synthase (FAD) activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0016740; Molecular function: transferase activity.
GO:0050797; Molecular function: thymidylate synthase (FAD) activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
Keywords
[?]
Features
[?]
From: PS51331 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | ThyX # | |||||||||
MOTIF | 80 | 90 | ThyX motif # | R-H-R-x(7,8)-S |
Additional information
[?]
Size range | 183-266 amino acids |
Related rules | None |
Repeats | 1-2 |
Topology | Undefined |
Example | O86840 (THYX_STRCO) |
Scope | Bacteria
Archaea
Viruses
Eukaryota; Dictyostelium |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]