PRU00661

Accession	PRU00661
Dates	14-APR-2009 (Created) 21-NOV-2019 (Last updated, Version 14)

Data class

Domain

Predictors

PROSITE; PS51331; THYX

Name	Flavin-dependent thymidylate synthase (thyX) domain

Function

The thyx domain contains FAD and methylates dUMP at position 5 of the pyrimidine ring.

AltName: Full=Probable thymidylate synthase; Short=TS; Short=TSase; EC 2.1.1.148;

Function	Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Catalytic activity	RHEA:29043: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) EC 2.1.1.148
Cofactor	FAD synthase) domain

GO:0008168; Molecular function: methyltransferase activity.
GO:0016740; Molecular function: transferase activity.
GO:0050797; Molecular function: thymidylate synthase (FAD) activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.

FAD
Flavoprotein
Methyltransferase
Nucleotide biosynthesis
Transferase

From: PS51331

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

ThyX #

MOTIF

80

90

ThyX motif #

R-H-R-x(7,8)-S

Size range	183-266 amino acids
Related rules	None
Repeats	1-2
Topology	Undefined
Example	O86840 (THYX_STRCO)
Scope	Bacteria Archaea Viruses Eukaryota; Dictyostelium
Comments	None

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• UniProtKB/Swiss-Prot sets
  

  Archaea	[13]
  Bacteria	[64]
  Eukaryota	[1]
  Viruses	[4]
  All	[ 82 ]

  
  
• Retrieve set of proteins with 3D structure for this domain