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annotation rule: PRU00661

General rule information [?]

Accession PRU00661
Dates 14-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain
Predictors PROSITE; PS51331; THYX
Name Flavin-dependent thymidylate synthase (thyX) domain
Function The thyx domain contains FAD and methylates dUMP at position 5 of the pyrimidine ring.

Propagated annotation [?]


Description [?]

case not <Triggered>
AltName: Full=Probable thymidylate synthase; Short=TS; Short=TSase; EC 2.1.1.148;
end case


Comments [?]

Function Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Catalytic activity RHEA:29043: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
EC 2.1.1.148
Cofactor FAD synthase) domain

Gene Ontology [?]

GO:0008168; Molecular function: methyltransferase activity.
GO:0016740; Molecular function: transferase activity.
GO:0050797; Molecular function: thymidylate synthase (FAD) activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.

Keywords [?]


Features [?]

From: PS51331
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ThyX #        
MOTIF     80     90       ThyX motif #     R-H-R-x(7,8)-S  

Additional information [?]

Size range 183-266 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example O86840 (THYX_STRCO)
Scope
Bacteria
Archaea
Viruses
Eukaryota; Dictyostelium
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]