General rule information
[?]
Accession |
PRU00678 |
Dates |
18-DEC-2007 (Created) 19-NOV-2022 (Last updated, Version 10) |
Predictors |
PROSITE; PS51346; PROKAR_ZN_DEPEND_PLPC_2
|
Name |
Prokaryotic zinc-dependent phospholipase C domain |
Function |
Phospholipase C (EC 3.1.4.3) has a ~245 amino-acids domain with the active site (PLC) in a cleft which is also occupied by 3 zinc ions. There are nine conserved residues known to be involved in binding the zinc ions: 5 His, 2 Asp, 1 Glu and 1 Trp. |
Propagated annotation
[?]
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
+ AltName: Full=phospholipase C;
EC 3.1.4.3;
Short=PLC; |
Catalytic activity |
RHEA:10604: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine
EC 3.1.4.3
|
Cofactor |
Zn(2+) Note: Binds 3 Zn(2+) ions per subunit. |
Subcellular location |
Secreted. |
end case
Similarity |
Belongs to the bacterial zinc-metallophospholipase C family. |
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
PROSITE |
PS00384; PROKAR_ZN_DEPEND_PLPC_1; 1; |
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case
From: PS51346 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
3
|
|
to
|
|
Zn-dependent PLC #
|
|
|
|
|
|
|
BINDING
|
|
4
|
|
4
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
W
|
|
1
|
BINDING
|
|
14
|
|
14
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
H
|
|
1
|
BINDING
|
|
59
|
|
59
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3
|
|
|
|
D
|
|
3
|
BINDING
|
|
71
|
|
71
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3
|
|
|
|
H
|
|
3
|
BINDING
|
|
129
|
|
129
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3
|
|
|
|
H
|
|
3
|
BINDING
|
|
133
|
|
133
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
D
|
|
1
|
BINDING
|
|
133
|
|
133
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3
|
|
|
|
D
|
|
3
|
BINDING
|
|
139
|
|
139
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2
|
|
|
|
H
|
|
2
|
BINDING
|
|
151
|
|
151
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2
|
|
|
|
H
|
|
2
|
BINDING
|
|
155
|
|
155
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2
|
|
|
|
E
|
|
2
|
Additional information
[?]
Size range |
230-260 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q46150 (PHLC_CLONO) |
Scope |
Bacteria |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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