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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00692


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00692
General rule information [?]

Accession PRU00692
Dates 31-JAN-2008 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51359; COX5B_2
Name Cytochrome c oxidase subunit Vb, zinc binding domain
Function This domain occurs in a subunit which forms a part of the cytochrome c oxidase (EC 1.9.3.1) enzymatic complex. It contains 3 to 4 conserved cysteine residues which bind a zinc atom.
Scope(s) Eukaryota
Example(s) Q5S3G4;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <Feature:PS51359:61=C> and <Feature:PS51359:84=C> and <Feature:PS51359:87=C>
Protein name + AltName: Full=cytochrome c oxidase subunit;

Comments [?]

FUNCTIONThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
SUBCELLULAR LOCATIONMitochondrion inner membrane.
end case
SIMILARITYBelongs to the cytochrome c oxidase Vb family.

Keywords [?]

Mitochondrion inner membrane
Membrane
Metal-binding
Mitochondrion
Zinc
end case

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0046872; Molecular function:metal ion binding
GO:0005739; Cellular component:mitochondrion
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS00848; COX5B_1; 1;

Features [?]

From: PS51359
Key From To Description Tag Condition FTGroup
BINDING 61 61 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C
BINDING 63 63 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C
BINDING 84 84 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C
BINDING 87 87 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C

Additional information [?]

Size range 90-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]