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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00734


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PURL: https://purl.expasy.org/prosite/rule/PRU00734
General rule information [?]

Accession PRU00734
Dates 19-DEC-2008 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51401; CHORD
Name CHORD domain
Function Cysteine- and histidine-rich domains (CHORDs) are 60-amino acid modules that bind two zinc ions.
Scope(s) Eukaryota
Example(s) Q9UHD1;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
Zinc
Metal-binding
end case

Features [?]

From: PS51401
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CHORD #"
BINDING 1 1 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 2
BINDING 38 38 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2
BINDING 39 39 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2
BINDING 60 60 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 1

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]