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annotation rule: PRU00761

General rule information [?]

Accession PRU00761
Dates 13-MAR-2009 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51431; KAIA_C
Name KaiA C-terminal domain
Function KaiA activation most likely involves direct protein-protein interactions of the N- terminal domain that result in functional modulation of the C-terminal effector domain.

Propagated annotation [?]


Comments [?]

Function Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer phosphorylation.
Subunit Homodimer. Component of the kaiABC complex, at least composed of a kaiC homohexamer, a kaiB dimer and two kaiA dimers. The kaiABC complex also interacts with sasA.
Domain The kaiA domain mediates the interaction with kaiC, the homodimerization, and is responsible for the clock oscillation function.

Gene Ontology [?]

GO:0007623; Biological process: circadian rhythm.

Keywords [?]


Features [?]

From: PS51431
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       KaiA C-terminal #        

Additional information [?]

Size range 100-110 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6L8L7 (KAIA_SYNP2)
Scope
Bacteria; Cyanobacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]