ProRule PRU00761
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00761 |
| Accession | PRU00761 |
| Dates | 13-MAR-2009 (Created)
17-FEB-2023 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51431; KAIA_C |
Name | KaiA C-terminal domain |
| Function | KaiA activation most likely involves direct protein-protein interactions of the N- terminal domain that result in functional modulation of the C-terminal effector domain. |
| Scope(s) |
Bacteria Cyanobacteriota |
| Example(s) | Q6L8L7 (KAIA_PICP2); |
Propagated annotation
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Comments
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| FUNCTION | Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer phosphorylation. |
| SUBUNIT | Homodimer. Component of the kaiABC complex, at least composed of a kaiC homohexamer, a kaiB dimer and two kaiA dimers. The kaiABC complex also interacts with sasA. |
| DOMAIN | The kaiA domain mediates the interaction with kaiC, the homodimerization, and is responsible for the clock oscillation function. |
Keywords
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Gene Ontology
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| GO:0007623; Biological process:circadian rhythm |
Features
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| From: PS51431 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="KaiA C-terminal #" | |||||||||
Additional information
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| Size range | 100-110 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain