PRU00761

Accession	PRU00761
Dates	13-MAR-2009 (Created) 17-FEB-2023 (Last updated, Version 5)

Data class

Domain

Predictors

PROSITE; PS51431; KAIA_C

Name	KaiA C-terminal domain

Function

KaiA activation most likely involves direct protein-protein interactions of the N- terminal domain that result in functional modulation of the C-terminal effector domain.

Function	Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer phosphorylation.
Subunit	Homodimer. Component of the kaiABC complex, at least composed of a kaiC homohexamer, a kaiB dimer and two kaiA dimers. The kaiABC complex also interacts with sasA.
Domain	The kaiA domain mediates the interaction with kaiC, the homodimerization, and is responsible for the clock oscillation function.

GO:0007623; Biological process: circadian rhythm.

Biological rhythms

From: PS51431

Key

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KaiA C-terminal #

Size range	100-110 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q6L8L7 (KAIA_SYNP2)
Scope	Bacteria; Cyanobacteriota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Bacteria

  [8]

  
  
• Retrieve set of proteins with 3D structure for this domain