PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00761


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00761
General rule information [?]

Accession PRU00761
Dates 13-MAR-2009 (Created)
17-FEB-2023 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51431; KAIA_C
Name KaiA C-terminal domain
Function KaiA activation most likely involves direct protein-protein interactions of the N- terminal domain that result in functional modulation of the C-terminal effector domain.
Scope(s) Bacteria
Cyanobacteriota
Example(s) Q6L8L7;

Propagated annotation [?]

Comments [?]

FUNCTIONComponent of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer phosphorylation.
SUBUNITHomodimer. Component of the kaiABC complex, at least composed of a kaiC homohexamer, a kaiB dimer and two kaiA dimers. The kaiABC complex also interacts with sasA.
DOMAINThe kaiA domain mediates the interaction with kaiC, the homodimerization, and is responsible for the clock oscillation function.

Keywords [?]

Biological rhythms

Gene Ontology [?]

GO:0007623; Biological process:circadian rhythm

Features [?]

From: PS51431
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="KaiA C-terminal #"

Additional information [?]

Size range 100-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]