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annotation rule: PRU00766

General rule information [?]

Accession PRU00766
Dates 23-MAR-2012 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Name Potyvirus NIa protease (NIa-pro) domain
Function The potyvirus NIa-pro has a His-Asp-Cys catalytic triad, which is homologous to the trypsin-like proteases except for Cys replacing Ser.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

end case

Features [?]

From: PS51436
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C4 #        
ACT_SITE     46     46       For nuclear inclusion protein A activity     H   1
ACT_SITE     81     81       For nuclear inclusion protein A activity     D   1
ACT_SITE     151     151       For nuclear inclusion protein A activity     C   1

Additional information [?]

Size range 942-3491 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P89509 (POLG_TUMVJ)
Viruses; Potyviridae
Comments None


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UniProtKB rule member sequences [?]