ProRule PRU00766
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00766 |
| Accession | PRU00766 |
| Dates | 23-MAR-2012 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51436; POTYVIRUS_NIA_PRO |
Name | Potyvirus NIa protease (NIa-pro) domain |
| Function | The potyvirus NIa-pro has a His-Asp-Cys catalytic triad, which is homologous to the trypsin-like proteases except for Cys replacing Ser. |
| Scope(s) |
Viruses Potyviridae |
| Example(s) | P89509 (POLG_TUMVJ); |
Propagated annotation
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Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0008233; Molecular function:peptidase activity | |
| GO:0006508; Biological process:proteolysis | |
| GO:0004197; Molecular function:cysteine-type endopeptidase activity | |
Features
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| From: PS51436 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C4 #" | |||||||||
| ACT_SITE | 46 | 46 | /note="For nuclear inclusion protein A activity" | H | 1 | |||||||
| ACT_SITE | 81 | 81 | /note="For nuclear inclusion protein A activity" | D | 1 | |||||||
| ACT_SITE | 151 | 151 | /note="For nuclear inclusion protein A activity" | C | 1 | |||||||
Additional information
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| Size range | 942-3491 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [38] All [ 38 ]
- Retrieve set of proteins with 3D structure for this domain