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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00766


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00766
General rule information [?]

Accession PRU00766
Dates 23-MAR-2012 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51436; POTYVIRUS_NIA_PRO
Name Potyvirus NIa protease (NIa-pro) domain
Function The potyvirus NIa-pro has a His-Asp-Cys catalytic triad, which is homologous to the trypsin-like proteases except for Cys replacing Ser.
Scope(s) Viruses
Potyviridae
Example(s) P89509;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0006508; Biological process:proteolysis
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51436
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C4 #"
ACT_SITE 46 46 /note="For nuclear inclusion protein A activity" H 1
ACT_SITE 81 81 /note="For nuclear inclusion protein A activity" D 1
ACT_SITE 151 151 /note="For nuclear inclusion protein A activity" C 1

Additional information [?]

Size range 942-3491 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]