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annotation rule: PRU00770

General rule information [?]

Accession PRU00770
Dates 2-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51439; MENTAL
Name MENTAL domain
Function The ~170-amino acid MENTAL (MLN64 N-terminal) domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol.

Propagated annotation [?]

Computed features [?]

General Transmembrane; -; 4;

Gene Ontology [?]

GO:0015485; Molecular function: cholesterol binding.
GO:0120020; Molecular function: cholesterol transfer activity.
GO:0005768; Cellular component: endosome.
GO:0008289; Molecular function: lipid binding.
GO:0006869; Biological process: lipid transport.
GO:0016020; Cellular component: membrane.
GO:0006810; Biological process: transport.

Keywords [?]

Features [?]

From: PS51439
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MENTAL #        

Additional information [?]

Size range 170-175 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q14849 (STAR3_HUMAN)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]