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| annotation rule: PRU00770 |
General rule information
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| Accession | PRU00770 |
| Dates | 2-APR-2009 (Created) 21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51439; MENTAL |
| Name | MENTAL domain |
| Function | The ~170-amino acid MENTAL (MLN64 N-terminal) domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol. |
Propagated annotation
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Computed features
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| General | Transmembrane; -; 4; |
Gene Ontology
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GO:0015485; Molecular function: cholesterol binding.
GO:0120020; Molecular function: cholesterol transfer activity.
GO:0005768; Cellular component: endosome.
GO:0008289; Molecular function: lipid binding.
GO:0006869; Biological process: lipid transport.
GO:0016020; Cellular component: membrane.
GO:0006810; Biological process: transport.
GO:0120020; Molecular function: cholesterol transfer activity.
GO:0005768; Cellular component: endosome.
GO:0008289; Molecular function: lipid binding.
GO:0006869; Biological process: lipid transport.
GO:0016020; Cellular component: membrane.
GO:0006810; Biological process: transport.
Keywords
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Features
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| From: PS51439 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | MENTAL # | |||||||||
Additional information
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| Size range | 170-175 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q14849 (STAR3_HUMAN) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [8]
- Retrieve set of proteins with 3D structure for this domain