ProRule PRU00770
General rule information
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| Accession | PRU00770 |
| Dates | 2-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51439; MENTAL |
Name | MENTAL domain |
| Function | The ~170-amino acid MENTAL (MLN64 N-terminal) domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q14849 (STAR3_HUMAN); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0015485; Molecular function:cholesterol binding |
| GO:0120020; Molecular function:cholesterol transfer activity |
| GO:0005768; Cellular component:endosome |
| GO:0008289; Molecular function:lipid binding |
| GO:0006869; Biological process:lipid transport |
| GO:0016020; Cellular component:membrane |
| GO:0006810; Biological process:transport |
Cross-references
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| General | Transmembrane; -; 4; |
Features
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| From: PS51439 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MENTAL #" | |||||||||
Additional information
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| Size range | 170-175 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain