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ProRule PRU00770


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PURL: https://purl.expasy.org/prosite/rule/PRU00770
General rule information [?]

Accession PRU00770
Dates 02-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51439; MENTAL
Name MENTAL domain
Function The ~170-amino acid MENTAL (MLN64 N-terminal) domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol.
Scope(s) Eukaryota
Metazoa
Example(s) Q14849;

Propagated annotation [?]

Keywords [?]

Endosome
Lipid-binding
Lipid transport
Membrane
Transport

Gene Ontology [?]

GO:0015485; Molecular function:cholesterol binding
GO:0120020; Molecular function:cholesterol transfer activity
GO:0005768; Cellular component:endosome
GO:0008289; Molecular function:lipid binding
GO:0006869; Biological process:lipid transport
GO:0016020; Cellular component:membrane
GO:0006810; Biological process:transport

Cross-references [?]

General Transmembrane; -; 4;

Features [?]

From: PS51439
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MENTAL #"

Additional information [?]

Size range 170-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]