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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00770


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00770
General rule information [?]

Accession PRU00770
Dates 02-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51439; MENTAL
Name MENTAL domain
Function The ~170-amino acid MENTAL (MLN64 N-terminal) domain mediates MLN64 and MENTHO homo- and hetero-interactions, targets both proteins to late endosomes and binds cholesterol.
Scope(s) Eukaryota
Metazoa
Example(s) Q14849;

Propagated annotation [?]

Keywords [?]

Endosome
Lipid-binding
Lipid transport
Membrane
Transport

Gene Ontology [?]

GO:0015485; Molecular function:cholesterol binding
GO:0120020; Molecular function:cholesterol transfer activity
GO:0005768; Cellular component:endosome
GO:0008289; Molecular function:lipid binding
GO:0006869; Biological process:lipid transport
GO:0016020; Cellular component:membrane
GO:0006810; Biological process:transport

Cross-references [?]

General Transmembrane; -; 4;

Features [?]

From: PS51439
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MENTAL #"

Additional information [?]

Size range 170-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]