We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00783
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00783
General rule information
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| Accession | PRU00783 |
| Dates | 19-JUN-2009 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50146; DAGK |
Name | DAG-kinase catalytic (DAGKc) domain |
| Function | The DAG-kinase catalytic domain (DAGKc) is present in mammalian lipid kinases, such as diacylglycerol (DAG), ceramide and sphingosine kinases, as well as in related bacterial lipid kinases. |
| Scope(s) |
Bacteria Eukaryota Archaea |
| Example(s) | Q6GFF9; Q87ZA2; Q03603; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.7.-.-; |
Keywords
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| ATP-binding | |
| end case | |
| Kinase | |
| Transferase | |
Gene Ontology
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| GO:0016740; Molecular function:transferase activity | |
| GO:0016301; Molecular function:kinase activity | |
| case <FTGroup:1> | |
| GO:0005524; Molecular function:ATP binding | |
Features
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| From: PS50146 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DAGKc #" | |||||||||
| BINDING | 11 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
1 | ||||||||
| BINDING | 69 | 75 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
1 | ||||||||
| BINDING | 43 | 43 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST] | 1 | |||||||
| BINDING | 100 | 100 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST] | 1 | |||||||
Additional information
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| Size range | 110-195 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [125] Eukaryota [76] All [ 201 ]
- Retrieve set of proteins with 3D structure for this domain