We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00793
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00793
General rule information
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| Accession | PRU00793 |
| Dates | 27-JUL-2009 (Created)
21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51461; NC1_FIB |
Name | Fibrillar collagen C-terminal non-collagenous (NC1) domain |
| Function | The NC1 domain is the most conserved part of fibrillar collagens from invertebrates to vertebrates (types I-III, V, XI, XXIV and XXVII). |
| Scope(s) |
Eukaryota |
| Example(s) | P02452; |
Propagated annotation
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Comments
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| case <OC:Metazoa> | |
| SUBCELLULAR LOCATION | Secreted, extracellular space, extracellular matrix. |
| end case | |
| case <OC:Metazoa> | |
| SIMILARITY | Belongs to the fibrillar collagen family. |
Keywords
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Gene Ontology
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| GO:0005615; Cellular component:extracellular space |
| GO:0005201; Molecular function:extracellular matrix structural constituent |
Features
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| From: PS51461 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Fibrillar collagen NC1 #" | |||||||||
| DISULFID | 31 | 31 | /note="Interchain" | disulf | C | |||||||
| DISULFID | 37 | 37 | /note="Interchain" | disulf | C | |||||||
| DISULFID | 54 | 54 | /note="Interchain" | disulf | C | |||||||
| DISULFID | 63 | 63 | /note="Interchain" | disulf | C | |||||||
| DISULFID | 72 | 225 | disulf | C-x*-C | ||||||||
| DISULFID | 133 | 178 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 185-251 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-4 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [60] All [ 60 ]
- Retrieve set of proteins with 3D structure for this domain