We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00794
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00794
General rule information
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| Accession | PRU00794 |
| Dates | 02-OCT-2009 (Created)
21-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51462; NUDIX |
Name | Nudix hydrolase domain |
| Function | The Nudix superfamily is widespread among eucaryotes, bacteria, archaea and viruses and consists mainly of pyrophosphohydrolases that act upon substrates of general structure NUcleoside DIphosphate linked to another moiety, X (NDP-X) to yield NMP plus P-X. |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | Q5RD76; |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0016787; Molecular function:hydrolase activity |
| GO:0046872; Molecular function:metal ion binding |
Cross-references
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Features
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| From: PS51462 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Nudix hydrolase #" | |||||||||
| MOTIF | 36 | 57 | /note="Nudix box #" | |||||||||
Additional information
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| Size range | 105-260 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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