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ProRule PRU00819
General rule information
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| Accession | PRU00819 |
| Dates | 24-JUN-2010 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51486; REKLES |
Name | REKLES domain |
| Function | REKLES consists of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved C-terminal REKLESbeta. REKLESalpha and -beta are required, respectively, for nuclear entry and export of Bright during its nucleoplasmic shuttling. In addition to its function in nuclear export, the REKLESbeta subdomain regulates the binding of Bright to nuclear matrix association (or attachment) regions (MARs), its self- and paralogous (Bdp) association and stoichiometry, and its retention within the nuclear matrix. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | A2BEA6 (ARI3A_DANRE); |
Propagated annotation
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Features
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| From: PS51486 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="REKLES #" | |||||||||
Additional information
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| Size range | 76-119 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [13] All [ 13 ]
- Retrieve set of proteins with 3D structure for this domain