ProRule PRU00819

General rule information [?]

Accession PRU00819
Dates 24-JUN-2010 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51486; REKLES
Name REKLES domain
Function REKLES consists of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved C-terminal REKLESbeta. REKLESalpha and -beta are required, respectively, for nuclear entry and export of Bright during its nucleoplasmic shuttling. In addition to its function in nuclear export, the REKLESbeta subdomain regulates the binding of Bright to nuclear matrix association (or attachment) regions (MARs), its self- and paralogous (Bdp) association and stoichiometry, and its retention within the nuclear matrix.
Scope(s) Eukaryota
Example(s) A2BEA6 (ARI3A_DANRE);

Propagated annotation [?]

Features [?]

From: PS51486
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="REKLES #"

Additional information [?]

Size range 76-119 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]