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annotation rule: PRU00819

General rule information [?]

Accession PRU00819
Dates 24-JUN-2010 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51486; REKLES
Name REKLES domain
Function REKLES consists of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved C-terminal REKLESbeta. REKLESalpha and -beta are required, respectively, for nuclear entry and export of Bright during its nucleoplasmic shuttling. In addition to its function in nuclear export, the REKLESbeta subdomain regulates the binding of Bright to nuclear matrix association (or attachment) regions (MARs), its self- and paralogous (Bdp) association and stoichiometry, and its retention within the nuclear matrix.

Propagated annotation [?]

Features [?]

From: PS51486
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       REKLES #        

Additional information [?]

Size range 76-119 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A2BEA6 (ARI3A_DANRE)
Eukaryota; Metazoa
Comments None


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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [13]