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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00826


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00826
General rule information [?]

Accession PRU00826
Dates 23-MAY-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51493; AV_NSP4_PRO
Name Arterivirus nsp4 proteinase domain
Function The arterivirus nsp4 proteinase domain forms peptidase family S32.
Scope(s) Viruses
Arteriviridae
Example(s) Q9YN02;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Serine protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0004252; Molecular function:serine-type endopeptidase activity
GO:0019082; Biological process:viral protein processing

Features [?]

From: PS51493
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S32 #"
ACT_SITE 39 39 /note="Charge relay system; for 3C-like serine proteinase activity" H 1
ACT_SITE 64 64 /note="Charge relay system; for 3C-like serine proteinase activity" D 1
ACT_SITE 117 117 /note="Charge relay system; for 3C-like serine proteinase activity" S 1

Additional information [?]

Size range 191-214 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]