We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00851
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00851
General rule information
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| Accession | PRU00851 |
| Dates | 22-DEC-2011 (Created)
27-JUN-2022 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51518; SGF29_C |
Name | SGF29 C-terminal domain |
| Function | The SGF29 C-terminal domain contains a double Tudor-like motif that binds the H3K4me2/3 lysine methylation site on the N terminus of histone H3. |
| Scope(s) |
Eukaryota |
| Example(s) | Q96ES7; |
Propagated annotation
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Comments
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| DOMAIN | The SGF29 tudor-like domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me). |
| SIMILARITY | Belongs to the SGF29 family. |
Keywords
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Gene Ontology
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| GO:0006325; Biological process:chromatin organization |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
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| From: PS51518 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="SGF29 C-terminal #" | |||||||||
| REGION | 44 | 46 | /note="Histone H3K4me3 N-terminus binding" | D-x*-[DE] | 1 | |||||||
| case <FTGroup:1> | ||||||||||||
| REGION | 91 | 94 | /note="Histone H3K4me3 N-terminus binding" | |||||||||
| end case | ||||||||||||
| REGION | 115 | 118 | /note="Histone H3K4me3 binding" | F-x* | 1 | |||||||
| SITE | 89 | 89 | /note="Histone H3K4me3 binding" | Y | 1 | |||||||
| SITE | 96 | 96 | /note="Histone H3K4me3 binding" | Y | 1 | |||||||
Additional information
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| Size range | 126-152 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [9] All [ 9 ]
- Retrieve set of proteins with 3D structure for this domain