ProRule PRU00851
General rule information
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| Accession | PRU00851 |
| Dates | 22-DEC-2011 (Created)
27-JUN-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51518; SGF29_C |
Name | SGF29 C-terminal domain |
| Function | The SGF29 C-terminal domain contains a double Tudor-like motif that binds the H3K4me2/3 lysine methylation site on the N terminus of histone H3. |
| Scope(s) |
Eukaryota |
| Example(s) | Q96ES7 (SGF29_HUMAN); |
Propagated annotation
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Comments
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| DOMAIN | The SGF29 tudor-like domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me). |
| SIMILARITY | Belongs to the SGF29 family. |
Keywords
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Gene Ontology
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| GO:0006325; Biological process:chromatin organization |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
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| From: PS51518 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="SGF29 C-terminal #" | |||||||||
| REGION | 44 | 46 | /note="Histone H3K4me3 N-terminus binding" | D-x*-[DE] | 1 | |||||||
| case <FTGroup:1> | ||||||||||||
| REGION | 91 | 94 | /note="Histone H3K4me3 N-terminus binding" | |||||||||
| end case | ||||||||||||
| REGION | 115 | 118 | /note="Histone H3K4me3 binding" | F-x* | 1 | |||||||
| SITE | 89 | 89 | /note="Histone H3K4me3 binding" | Y | 1 | |||||||
| SITE | 96 | 96 | /note="Histone H3K4me3 binding" | Y | 1 | |||||||
Additional information
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| Size range | 126-152 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain