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annotation rule: PRU00851

General rule information [?]

Accession PRU00851
Dates 22-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51518; SGF29_C
Name SGF29 C-terminal domain
Function The SGF29 C-terminal domain contains a double Tudor-like motif that binds the H3K4me2/3 lysine methylation site on the N terminus of histone H3.

Propagated annotation [?]


Comments [?]

Domain The SGF29 tudor-like domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).
Similarity Belongs to the SGF29 family.

Gene Ontology [?]

GO:0006325; Biological process: chromatin organization.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]


Features [?]

From: PS51518
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       SGF29 C-terminal #        
REGION     44     46       Histone H3K4me3 N-terminus binding     D-x*-[DE]   1
case <FTGroup:1>
REGION     91     94       Histone H3K4me3 N-terminus binding        
end case

REGION     115     118       Histone H3K4me3 binding     F-x*   1
BINDING     89     89       Histone H3K4me3     Y   1
BINDING     96     96       Histone H3K4me3     Y   1

Additional information [?]

Size range 126-152 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q96ES7 (SGF29_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]