We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00858
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00858
General rule information
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| Accession | PRU00858 |
| Dates | 04-AUG-2011 (Created)
27-JUN-2022 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51526; RFX_DBD |
Name | RFX-type winged-helix DNA-binding domain |
| Function | The characteristic RFX-type HTH DNA binding domain has been recruited into otherwise very divergent regulatory factors functioning in a diverse spectrum of unrelated systems, including regulation of the mitotic cell cycle in fission yeast, the control of the immune response in mammals, and infection by human hepatitis B virus. |
| Scope(s) |
Eukaryota |
| Example(s) | P48379; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the RFX family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
| GO:0006351; Biological process:DNA-templated transcription |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
Features
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| From: PS51526 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | from | to | /note="RFX-type winged-helix #" | |||||||||
Additional information
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| Size range | 65-90 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [41] All [ 41 ]
- Retrieve set of proteins with 3D structure for this domain