PRU00859

General rule information [?]

Accession	PRU00859
Dates	9-JUN-2011 (Created) 30-SEP-2022 (Last updated, Version 9)

Data class

Domain

Predictors

PROSITE; PS51527; FLAVIVIRUS_NS2B

Name	Flavivirus NS2B domain

Function

The NS3pro has a classical serine protease catalytic triad (His, Asp, and Ser). The enzymatic activity of NS3pro is enhanced by interacting with the central 40 amino acid of NS2B which acts as an essential cofactor.

Propagated annotation [?]

Comments [?]

Function

Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.

Gene Ontology [?]

GO:0033644; Cellular component: host cell membrane.
GO:0016020; Cellular component: membrane.
GO:0044165; Cellular component: host cell endoplasmic reticulum.

Keywords [?]

Host membrane
Membrane
Transmembrane
Transmembrane helix
Host endoplasmic reticulum

Features [?]

From: PS51527

Key From To Description Tag Condition FTGroup

REGION 54 93 Interacts with and activates NS3 protease

Additional information [?]

Size range	120-143 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P07564 (POLG_DEN2J)
Scope	Viruses; Flavivirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [59]
Retrieve set of proteins with 3D structure for this domain