ProRule PRU00859

General rule information [?]

Accession PRU00859
Dates 9-JUN-2011 (Created)
30-SEP-2022 (Last updated, Version 9)
Data class Domain;
Name Flavivirus NS2B domain
Function The NS3pro has a classical serine protease catalytic triad (His, Asp, and Ser). The enzymatic activity of NS3pro is enhanced by interacting with the central 40 amino acid of NS2B which acts as an essential cofactor.
Scope(s) Viruses
Example(s) P07564 (POLG_DEN2J);

Propagated annotation [?]

Comments [?]

FUNCTIONSerine protease subunit NS2B: Required cofactor for the serine protease function of NS3.

Keywords [?]

Gene Ontology [?]

GO:0033644; Cellular component:host cell membrane
GO:0016020; Cellular component:membrane
GO:0044165; Cellular component:host cell endoplasmic reticulum

Features [?]

From: PS51527
Key From To Description Tag Condition FTGroup
REGION 54 93 /note="Interacts with and activates NS3 protease"

Additional information [?]

Size range 120-143 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]