ProRule PRU00859
General rule information
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| Accession | PRU00859 |
| Dates | 9-JUN-2011 (Created)
30-SEP-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51527; FLAVIVIRUS_NS2B |
Name | Flavivirus NS2B domain |
| Function | The NS3pro has a classical serine protease catalytic triad (His, Asp, and Ser). The enzymatic activity of NS3pro is enhanced by interacting with the central 40 amino acid of NS2B which acts as an essential cofactor. |
| Scope(s) |
Viruses Flavivirus |
| Example(s) | P07564 (POLG_DEN2J); |
Propagated annotation
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Comments
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| FUNCTION | Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3. |
Keywords
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Gene Ontology
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| GO:0033644; Cellular component:host cell membrane |
| GO:0016020; Cellular component:membrane |
| GO:0044165; Cellular component:host cell endoplasmic reticulum |
Features
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| From: PS51527 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 54 | 93 | /note="Interacts with and activates NS3 protease" | |||||||||
Additional information
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| Size range | 120-143 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [60] All [ 60 ]
- Retrieve set of proteins with 3D structure for this domain