We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00865
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00865
General rule information
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| Accession | PRU00865 |
| Dates | 11-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51533; ADD |
Name | ADD domain |
| Function | The ADD domain is present in chromatin-associated proteins that play a role in establishing and/or maintaining a normal pattern of DNA methylation. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q9UJW3; |
Propagated annotation
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Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| Zinc-finger | |
Gene Ontology
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| case (<Feature:PS51533:13=[CH]> and <Feature:PS51533:16=[CH]> and <Feature:PS51533:37=[CH]> and <Feature:PS51533:40=[CH]>) or (<Feature:PS51533:60=[CH]> and <Feature:PS51533:63=[CH]> and <Feature:PS51533:72=[CH]> and <Feature:PS51533:75=[CH]> and <Feature:PS51533:80=[CH]> and <Feature:PS51533:83=[CH]> and <Feature:PS51533:104=[CH]> and <Feature:PS51533:107=[CH]>) | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
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| From: PS51533 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ADD #" | |||||||||
| ZN_FING | 12 | 46 | /note="GATA-type #; atypical" | |||||||||
| ZN_FING | 57 | 111 | /note="PHD-type #; atypical" | |||||||||
Additional information
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| Size range | 86-148 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [17] All [ 17 ]
- Retrieve set of proteins with 3D structure for this domain