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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00868


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00868
General rule information [?]

Accession PRU00868
Dates 03-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51535; PESTIVIRUS_NS3PRO
Name Pestivirus NS3 protease (NS3pro) domain
Function The NS3 protease (NS3pro) domain is of some 180 aa with a catalytic triad of His-Asp-Ser.
Scope(s) Viruses
Pestivirus
Example(s) P19711;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Serine protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0008236; Molecular function:serine-type peptidase activity

Features [?]

From: PS51535
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S31 #"
ACT_SITE 69 69 /note="Charge relay system; for serine protease NS3 activity" H 1
ACT_SITE 106 106 /note="Charge relay system; for serine protease NS3 activity" D 1
ACT_SITE 163 163 /note="Charge relay system; for serine protease NS3 activity" S 1

Additional information [?]

Size range 164-184 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]