ProRule PRU00870
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00870 |
| Accession | PRU00870 |
| Dates | 9-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51537; NV_3CL_PRO |
Name | Norovirus 3C-like protease (NV 3CLpro) domain |
| Function | NV 3CLpros belong to the chymotrypsin-like protease family, in that they appear to have chymotrypsin-like folds. Whether the 3CLpro domain has a catalytic dyad of composed of histidine and cysteine or tryad of histidine, glutamate and cysteine remains controversial. |
| Scope(s) |
Viruses Norovirus |
| Example(s) | P54634 (POLG_LORDV); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + Contains: RecName: Full=3C-like protease; Short=3CLpro; EC=3.4.22.66; |
Comments
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| FUNCTION | 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation. |
| CATALYTIC ACTIVITY | Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=3.4.22.66; |
| PTM | Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein. |
| end case | |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008234; Molecular function:cysteine-type peptidase activity | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0008233; Molecular function:peptidase activity | |
Features
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| From: PS51537 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C37 #" | |||||||||
| ACT_SITE | 30 | 30 | /note="For 3CLpro activity" | H | 1 | |||||||
| ACT_SITE | 54 | 54 | /note="For 3CLpro activity" | E | 1 | |||||||
| ACT_SITE | 139 | 139 | /note="For 3CLpro activity" | C | 1 | |||||||
Additional information
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| Size range | 171-191 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [4] All [ 4 ]
- Retrieve set of proteins with 3D structure for this domain