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General rule information [?]

Accession PRU00870
Dates 9-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51537; NV_3CL_PRO
Name Norovirus 3C-like protease (NV 3CLpro) domain
Function NV 3CLpros belong to the chymotrypsin-like protease family, in that they appear to have chymotrypsin-like folds. Whether the 3CLpro domain has a catalytic dyad of composed of histidine and cysteine or tryad of histidine, glutamate and cysteine remains controversial.

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ Contains: RecName: Full=3C-like protease; Short=3CLpro; EC;

Comments [?]

Function 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.
Catalytic activity Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=;
Ptm Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008234; Molecular function: cysteine-type peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.

Keywords [?]

end case

Features [?]

From: PS51537
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C37 #        
ACT_SITE     30     30       For 3CLpro activity     H   1
ACT_SITE     54     54       For 3CLpro activity     E   1
ACT_SITE     139     139       For 3CLpro activity     C   1

Additional information [?]

Size range 171-191 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P54634 (POLG_LORDV)
Viruses; Norovirus
Comments None


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UniProtKB rule member sequences [?]