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| annotation rule: PRU00870 |
General rule information
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| Accession | PRU00870 |
| Dates | 9-AUG-2011 (Created) 21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51537; NV_3CL_PRO |
| Name | Norovirus 3C-like protease (NV 3CLpro) domain |
| Function | NV 3CLpros belong to the chymotrypsin-like protease family, in that they appear to have chymotrypsin-like folds. Whether the 3CLpro domain has a catalytic dyad of composed of histidine and cysteine or tryad of histidine, glutamate and cysteine remains controversial. |
Propagated annotation
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Description
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case <FTGroup:1>
| + Contains: RecName: Full=3C-like protease; Short=3CLpro; EC 3.4.22.66; |
Comments
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| Function | 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation. |
| Catalytic activity | Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=3.4.22.66; |
| Ptm | Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein. |
end case
Gene Ontology
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case <FTGroup:1>
GO:0008234; Molecular function: cysteine-type peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
Keywords
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end case
Features
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| From: PS51537 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase C37 # | |||||||||
| ACT_SITE | 30 | 30 | For 3CLpro activity | H | 1 | |||||||
| ACT_SITE | 54 | 54 | For 3CLpro activity | E | 1 | |||||||
| ACT_SITE | 139 | 139 | For 3CLpro activity | C | 1 | |||||||
Additional information
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| Size range | 171-191 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P54634 (POLG_LORDV) |
| Scope | Viruses; Norovirus |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [3]
- Retrieve set of proteins with 3D structure for this domain