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| annotation rule: PRU00881 |
General rule information
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| Accession | PRU00881 |
| Dates | 23-MAR-2012 (Created) 21-NOV-2019 (Last updated, Version 4) |
| Data class | Domain |
| Predictors | PROSITE; PS51548; BIRNAVIRUS_VP4_PRO |
| Name | Birnavirus VP4 protease domain |
| Function | The birnavirus VP4 protease domain displays a catalytic serine/ lysine dyad in its active site. |
Propagated annotation
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Comments
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case <FTGroup:1>
| Function | Protease VP4 is a serine protease that cleaves the polyprotein into its final products. Pre-VP2 is first partially cleaved, and may be completely processed by VP4 upon capsid maturation. |
end case
Gene Ontology
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case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008236; Molecular function: serine-type peptidase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008236; Molecular function: serine-type peptidase activity.
Keywords
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end case
Features
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| From: PS51548 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase S50 # | |||||||||
| ACT_SITE | 125 | 125 | Nucleophile | S | 1 | |||||||
| ACT_SITE | 163 | 163 | K | 1 | ||||||||
Additional information
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| Size range | 972-1069 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P22351 (POLS_IBDVS) |
| Scope | Viruses; Birnaviridae |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [15]
- Retrieve set of proteins with 3D structure for this domain