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annotation rule: PRU00881

General rule information [?]

Accession PRU00881
Dates 23-MAR-2012 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain
Name Birnavirus VP4 protease domain
Function The birnavirus VP4 protease domain displays a catalytic serine/ lysine dyad in its active site.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Function Protease VP4 is a serine protease that cleaves the polyprotein into its final products. Pre-VP2 is first partially cleaved, and may be completely processed by VP4 upon capsid maturation.
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008236; Molecular function: serine-type peptidase activity.

Keywords [?]

end case

Features [?]

From: PS51548
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase S50 #        
ACT_SITE     125     125       Nucleophile     S   1
ACT_SITE     163     163             K   1

Additional information [?]

Size range 972-1069 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P22351 (POLS_IBDVS)
Viruses; Birnaviridae
Comments None


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UniProtKB rule member sequences [?]