General rule information
[?]
Accession |
PRU00892 |
Dates |
29-MAR-2012 (Created) 21-NOV-2019 (Last updated, Version 15) |
Predictors |
PROSITE; PS51559; SAM_RMT2
|
Name |
Arginine and arginine-like N-methyltransferase. |
Function |
Guanidinoacetate N-methyltransferase (EC 2.1.1.2) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanidinoacetate to form creatine and S-adenosyl-L-homocysteine. |
Propagated annotation
[?]
case <OC:Chordata> and <Length>=210> and <Length<=280>
else
end case
case <OC:Chordata> and <Length>=210> and <Length<=280>
Catalytic activity |
RHEA:10656: guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.2
|
end case
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. |
case <OC:Chordata> and <Length>=210> and <Length<=280>
GO:0030731; Molecular function: guanidinoacetate N-methyltransferase activity.
else case (<OC:Fungi> or <OC:Viridiplantae>) and <Length>=315> and <Length<=540>
GO:0019702; Molecular function: protein-arginine N5-methyltransferase activity.
else
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
end case
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
From: PS51559 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
RMT2 #
|
|
|
|
|
|
|
REGION
|
|
69
|
|
74
|
|
S-adenosyl-L-methionine binding
|
|
|
|
[FH]-G-[LM]-[AGS]-[IL]-[AFISV]
|
|
|
REGION
|
|
90
|
|
92
|
|
S-adenosyl-L-methionine
|
|
|
|
E-[ACP]-[HN]
|
|
|
REGION
|
|
117
|
|
118
|
|
S-adenosyl-L-methionine binding
|
|
|
|
W-[EQ]
|
|
|
case <OC:Chordata> and <Length>=210> and <Length<=280>
REGION
|
|
169
|
|
170
|
|
Substrate binding
|
|
|
|
L-T
|
|
|
end case
BINDING
|
|
20
|
|
20
|
|
S-adenosyl-L-methionine
|
|
|
|
[FWY]
|
|
|
case <OC:Chordata> and <Length>=210> and <Length<=280>
BINDING
|
|
41
|
|
41
|
|
Substrate
|
|
|
|
M
|
|
|
BINDING
|
|
45
|
|
45
|
|
Substrate
|
|
|
|
E
|
|
|
end case
BINDING
|
|
49
|
|
49
|
|
S-adenosyl-L-methionine
|
|
|
|
[MS]
|
|
|
case <OC:Chordata> and <Length>=210> and <Length<=280>
BINDING
|
|
137
|
|
137
|
|
S-adenosyl-L-methionine and substrate
|
|
|
|
D
|
|
|
else
BINDING
|
|
137
|
|
137
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
end case
Additional information
[?]
Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P10868 (GAMT_RAT) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]