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annotation rule: PRU00892

General rule information [?]

Accession PRU00892
Dates 29-MAR-2012 (Created)
12-JAN-2021 (Last updated, Version 16)
Data class Domain
Predictors PROSITE; PS51559; SAM_RMT2
Name Arginine and arginine-like N-methyltransferase.
Function Guanidinoacetate N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanidinoacetate to form creatine and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

case <OC:Chordata> and <Length>=210> and <Length<=280>
+ RecName: EC;
+ RecName: EC 2.1.1.-;
end case

Comments [?]

case <OC:Chordata> and <Length>=210> and <Length<=280>
Catalytic activity RHEA:10656: guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine
end case

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.

Gene Ontology [?]

case <OC:Chordata> and <Length>=210> and <Length<=280>
GO:0030731; Molecular function: guanidinoacetate N-methyltransferase activity.
else case (<OC:Fungi> or <OC:Viridiplantae>) and <Length>=315> and <Length<=540>
GO:0019702; Molecular function: protein-arginine N5-methyltransferase activity.
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
end case

GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Features [?]

From: PS51559
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       RMT2 #        
REGION     69     74       S-adenosyl-L-methionine binding     [FH]-G-[LM]-[AGS]-[IL]-[AFISV]  
REGION     90     92       S-adenosyl-L-methionine     E-[ACP]-[HN]  
REGION     117     118       S-adenosyl-L-methionine binding     W-[EQ]  
case <OC:Chordata> and <Length>=210> and <Length<=280>
REGION     169     170       Guanidinoacetate binding     L-T  
end case

BINDING     20     20       S-adenosyl-L-methionine     [FWY]  
case <OC:Chordata> and <Length>=210> and <Length<=280>
BINDING     41     41       Guanidinoacetate     M  
BINDING     45     45       Guanidinoacetate     E  
end case

BINDING     49     49       S-adenosyl-L-methionine     [MS]  
case <OC:Chordata> and <Length>=210> and <Length<=280>
BINDING     137     137       S-adenosyl-L-methionine     D  
BINDING     137     137       Guanidinoacetate     D  
BINDING     137     137       S-adenosyl-L-methionine     D  
end case

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P10868 (GAMT_RAT)
Comments None


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UniProtKB rule member sequences [?]