ProRule PRU00893
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00893 |
| Accession | PRU00893 |
| Dates | 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
case c? <Length>=229> and <Length<=343>
PROSITE; PS51560; SAM_MT_NNT1 end case
|
Name | Nicotinamide N-methyltransferase (EC 2.1.1.1) |
| Function | Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Dikarya |
| Example(s) | Q9UT28 (EFM7_SCHPO); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNT1 family. |
Keywords
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Gene Ontology
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| GO:0008112; Molecular function:nicotinamide N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain