ProRule PRU00899
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00899 |
| Accession | PRU00899 |
| Dates | 25-NOV-2011 (Created)
3-SEP-2024 (Last updated, Version 18) |
| Data class | Domain; |
| Predictors |
case c? <Length>=847> and <Length<=1271>
PROSITE; PS51566; SAM_MT43_TRX_MLL end case
|
Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
| Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9M364 (ATX3_ARATH); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L- lysyl-[histone] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; |
| SIMILARITY | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. |
Keywords
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Gene Ontology
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| GO:0032259; Biological process:methylation |
| GO:0042054; Molecular function:histone methyltransferase activity |
| GO:0016740; Molecular function:transferase activity |
| GO:0008168; Molecular function:methyltransferase activity |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [3] All [ 3 ]
- Retrieve set of proteins with 3D structure for this domain