PRU00899

Accession	PRU00899
Dates	25-NOV-2011 (Created) 27-MAR-2023 (Last updated, Version 16)

Data class

Domain

Predictors

PROSITE; PS51566; SAM_MT43_TRX_MLL

Name	Histone-lysine N-methyltransferase (EC 2.1.1.43)

Function

Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

+ RecName: EC 2.1.1.-;

Catalytic activity	RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

GO:0032259; Biological process: methylation.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Methyltransferase
S-adenosyl-L-methionine
Transferase

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q9M364 (ATX3_ARATH)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB/Swiss-Prot sets

Eukaryota

[3]