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PRU00899


General rule information [?]

Accession PRU00899
Dates 25-NOV-2011 (Created)
27-MAR-2023 (Last updated, Version 16)
Data class Domain
case <Length>=847> and <Length<=1271>
Predictors PROSITE; PS51566; SAM_MT43_TRX_MLL
end case

Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

Gene Ontology [?]

GO:0032259; Biological process: methylation.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9M364 (ATX3_ARATH)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [3]