PRU00900
General rule information
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Accession | PRU00900 |
Dates | 25-NOV-2011 (Created) 30-SEP-2022 (Last updated, Version 11) |
Data class | Domain |
Predictors | PROSITE; PS51567; SAM_MT43_SUVAR420_1 |
Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.-; |
Comments
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Catalytic activity | RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. |
Gene Ontology
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GO:0042799; Molecular function: histone H4K20 methyltransferase activity.
Keywords
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Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q5AZY3 (SET9_EMENI) |
Scope | Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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