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| annotation rule: PRU00903 |
General rule information
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| Accession | PRU00903 |
| Dates | 25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain |
| Predictors | PROSITE; PS51570; SAM_MT43_SUVAR420_2 |
| Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
| Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.-; |
Comments
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| Catalytic activity | RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
| Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. |
Gene Ontology
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GO:0042799; Molecular function: histone methyltransferase activity (H4-K20 specific).
GO:0034773; Biological process: histone H4-K20 trimethylation.
GO:0034773; Biological process: histone H4-K20 trimethylation.
Keywords
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Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q86Y97 (KMT5C_HUMAN) |
| Scope | Eukaryota |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [14]
- Retrieve set of proteins with 3D structure for this domain