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annotation rule: PRU00903

General rule information [?]

Accession PRU00903
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51570; SAM_MT43_SUVAR420_2
Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Gene Ontology [?]

GO:0042799; Molecular function: histone methyltransferase activity (H4-K20 specific).
GO:0034773; Biological process: histone H4-K20 trimethylation.

Keywords [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q86Y97 (KMT5C_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]