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ProRule PRU00903


General rule information [?]

Accession PRU00903
Dates 25-NOV-2011 (Created)
1-MAR-2024 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51570; SAM_MT43_SUVAR420_2
Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Example(s) Q86Y97 (KMT5C_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0042799; Molecular function:histone H4K20 methyltransferase activity

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]