General rule information
[?]
Accession |
PRU00903 |
Dates |
25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 9) |
Predictors |
PROSITE; PS51570; SAM_MT43_SUVAR420_2
|
Name |
Histone-lysine N-methyltransferase (EC 2.1.1.43) |
Function |
Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
[?]
Catalytic activity |
RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
|
Similarity |
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. |
GO:0042799; Molecular function: histone methyltransferase activity (H4-K20 specific).
GO:0034773; Biological process: histone H4-K20 trimethylation.
Additional information
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Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q86Y97 (KMT5C_HUMAN) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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