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annotation rule: PRU00904 |
Accession | PRU00904 |
Dates | 25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 11) |
Data class | Domain |
Predictors | PROSITE; PS51571; SAM_MT43_PR_SET |
Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
+ RecName: EC 2.1.1.-; |
Catalytic activity | RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. |
From: PS51571 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 221 | 223 | S-adenosyl-L-methionine binding | |||||||||
REGION | 293 | 294 | S-adenosyl-L-methionine binding | |||||||||
BINDING | 266 | 266 | S-adenosyl-L-methionine | Y |
Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q0V9E9 (KMT5A_XENTR) |
Scope | Eukaryota |
Comments | None |
Eukaryota | [10] |