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annotation rule: PRU00904

General rule information [?]

Accession PRU00904
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51571; SAM_MT43_PR_SET
Name Histone-lysine N-methyltransferase (EC
Function Histone-lysine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

Gene Ontology [?]

GO:0018024; Molecular function: histone-lysine N-methyltransferase activity.

Keywords [?]

Features [?]

From: PS51571
Key     From     To       Description   Tag   Condition   FTGroup
REGION     221     223       S-adenosyl-L-methionine binding        
REGION     293     294       S-adenosyl-L-methionine binding        
BINDING     266     266       S-adenosyl-L-methionine     Y  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q0V9E9 (KMT5A_XENTR)
Comments None


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UniProtKB rule member sequences [?]