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annotation rule: PRU00904

General rule information [?]

Accession PRU00904
Dates 25-NOV-2011 (Created)
27-OCT-2018 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51571; SAM_MT43_PR_SET
Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC=2.1.1.43;

Comments [?]

Catalytic activity Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;.
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

Gene Ontology [?]

GO:0018024; Molecular function: histone-lysine N-methyltransferase activity.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Features [?]

From: PS51571
Key     From     To       Description   Tag   Condition   FTGroup
REGION     221     223       S-adenosyl-L-methionine binding        
REGION     293     294       S-adenosyl-L-methionine binding        
BINDING     266     266       S-adenosyl-L-methionine     Y  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q0V9E9 (KMT5A_XENTR)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]