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General rule information [?]

Accession PRU00905
Dates 25-NOV-2011 (Created)
27-MAR-2023 (Last updated, Version 15)
Data class Domain
case <Length>=891> and <Length<=1337>
Predictors PROSITE; PS51572; SAM_MT43_1
end case

Name Histone-lysine N-methyltransferase (EC
Function Histone-lysine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily.

Gene Ontology [?]

GO:0032259; Biological process: methylation.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q75D88 (SET1_ASHGO)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]