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annotation rule: PRU00906

General rule information [?]

Accession PRU00906
Dates 25-NOV-2011 (Created)
30-SEP-2022 (Last updated, Version 10)
Data class Domain
case <Length>=1010> and <Length<=1514>
Predictors PROSITE; PS51573; SAM_MT43_SUVAR39_1
end case

Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Gene Ontology [?]

GO:0018024; Molecular function: histone lysine N-methyltransferase activity.

Keywords [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q15047 (SETB1_HUMAN)
Scope
Eukaryota; Metazoa
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]