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ProRule PRU00906


General rule information [?]

Accession PRU00906
Dates 25-NOV-2011 (Created)
27-MAR-2023 (Last updated, Version 13)
Data class Domain;
Predictors
case c? <Length>=1010> and <Length<=1514>
PROSITE; PS51573; SAM_MT43_SUVAR39_1
end case
Name Histone-lysine N-methyltransferase (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Metazoa
Example(s) Q15047 (SETB1_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0032259; Biological process:methylation
GO:0042054; Molecular function:histone methyltransferase activity
GO:0034968; Biological process:histone lysine methylation
GO:0016740; Molecular function:transferase activity
GO:0008168; Molecular function:methyltransferase activity
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]