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annotation rule: PRU00912 |
Accession | PRU00912 |
Dates | 25-NOV-2011 (Created) 27-OCT-2018 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51579; SAM_MT43_SUVAR39_3 |
Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
+ RecName: EC=2.1.1.43; |
Catalytic activity | Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;. |
Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. |
Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q9EQQ0 (SUV92_MOUSE) |
Scope | Eukaryota |
Comments | None |
Eukaryota | [12] |