We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00914
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00914
General rule information
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| Accession | PRU00914 |
| Dates | 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51581; SAM_GTMT |
Name | Gammma-tocopherol O-methyltransferase (gTMT) |
| Function | Tocopherol O-methyltransferase (EC 2.1.1.95) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to gamma- tocopherol to form alpha-tocopherol and S-adenosyl-L-homocysteine. The cyanobacterial orthologue sll0418 (EC 2.1.1.295) methylates 2-methyl-6- phytyl-1,4-benzoquinone/2-methyl-6-solanyl-1,4-benzoquinone (MPBQ/MSBQ) to yield 2,3-dimethyl-5-phytylbenzoquinone/2,3-dimethyl/plastoquinol-9. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q6WEE4; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. |
Keywords
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Gene Ontology
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| GO:0032259; Biological process:methylation |
Features
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| From: PS51581 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 76 | 85 | /note="SAM motif I" | |||||||||
| REGION | 139 | 147 | /note="SAM motif II" | |||||||||
| REGION | 166 | 175 | /note="SAM motif III" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [1] Eukaryota [11] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain