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annotation rule: PRU00918

General rule information [?]

Accession PRU00918
Dates 25-NOV-2011 (Created)
26-SEP-2014 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51585; SAM_MT_TPMT
Name Thiopurine or thiol or thiocyanate S-methyltransferase (TPMT).
Function Thiol S-methyltransferase (EC 2.1.1.9) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiol to form a thioether and S-adenosyl-L-homocysteine. Thiocyanate S-methyltransferase (EC 2.1.1.n4) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to thiocyanate to form methyl thiocyanate and S-adenosyl-L-homocysteine. Thiopurine S-methyltransferase (EC 2.1.1.67) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiopurine to form methyl a thiopurine S-methylether and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC=2.1.1.-;

Comments [?]

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

Gene Ontology [?]

GO:0008172; Molecular function: S-methyltransferase activity.
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0032259; Biological process: methylation.

Keywords [?]


Features [?]

From: PS51585
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     70     70       S-adenosyl-L-methionine     W  
BINDING     125     125       S-adenosyl-L-methionine     D  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6AWU6 (HOL3_ARATH)
Scope
Eukaryota; Brassicaceae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]