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ProRule PRU00918
General rule information
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| Accession | PRU00918 |
| Dates | 25-NOV-2011 (Created)
19-NOV-2022 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51585; SAM_MT_TPMT |
Name | Thiopurine or thiol or thiocyanate S-methyltransferase (TPMT). |
| Function | Thiol S-methyltransferase (EC 2.1.1.9) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiol to form a thioether and S-adenosyl-L-homocysteine. Thiocyanate S-methyltransferase (EC 2.1.1.n4) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to thiocyanate to form methyl thiocyanate and S-adenosyl-L-homocysteine. Thiopurine S-methyltransferase (EC 2.1.1.67) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiopurine to form methyl a thiopurine S-methylether and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Brassicaceae |
| Example(s) | Q6AWU6 (HOL3_ARATH); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. |
Keywords
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Gene Ontology
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| GO:0008172; Molecular function:S-methyltransferase activity |
| GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity |
| GO:0032259; Biological process:methylation |
Features
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| From: PS51585 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 70 | 70 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
| BINDING | 125 | 125 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [74] Eukaryota [25] All [ 99 ]
- Retrieve set of proteins with 3D structure for this domain