PROSITE

Accession	PRU00918
Dates	25-NOV-2011 (Created) 14-MAY-2022 (Last updated, Version 12)

Data class

Domain

Predictors

PROSITE; PS51585; SAM_MT_TPMT

Name	Thiopurine or thiol or thiocyanate S-methyltransferase (TPMT).

Function

Thiol S-methyltransferase (EC 2.1.1.9) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiol to form a thioether and S-adenosyl-L-homocysteine. Thiocyanate S-methyltransferase (EC 2.1.1.n4) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to thiocyanate to form methyl thiocyanate and S-adenosyl-L-homocysteine. Thiopurine S-methyltransferase (EC 2.1.1.67) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a thiopurine to form methyl a thiopurine S-methylether and S-adenosyl-L-homocysteine.

+ RecName: EC 2.1.1.-;

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

GO:0008172; Molecular function: S-methyltransferase activity.
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0032259; Biological process: methylation.

Methyltransferase
S-adenosyl-L-methionine
Transferase

From: PS51585

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

70

70

/ligand="S-adenosyl-L-methionine" /ligand_id="59789

W

BINDING

125

125

/ligand="S-adenosyl-L-methionine" /ligand_id="59789

D

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q6AWU6 (HOL3_ARATH)
Scope	Eukaryota; Brassicaceae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Bacteria	[74]
  Eukaryota	[25]
  All	[ 99 ]

  
  
• Retrieve set of proteins with 3D structure for this domain