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annotation rule: PRU00922

General rule information [?]

Accession PRU00922
Dates 25-NOV-2011 (Created)
2-JUL-2019 (Last updated, Version 11)
Data class Domain
case <Length>=756> and <Length<=1134>
Predictors PROSITE; PS51589; SAM_MT56_VP3
end case

Name Viral protein 3 containing mRNA (guanine-N(7)-)-methyltransferase.
Function mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC=2.1.1.56;

Comments [?]

Catalytic activity Reaction=a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11220, Rhea:RHEA-COMP:12925, Rhea:RHEA-COMP:13407, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:133968, ChEBI:CHEBI:136896; EC=2.1.1.56;.

Gene Ontology [?]

GO:0004482; Molecular function: mRNA (guanine-N7-)-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q65526 (VP3_ROTBS)
Scope
Viruses
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]