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ProRule PRU00922


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00922
Accession PRU00922
Dates 25-NOV-2011 (Created)
11-JAN-2024 (Last updated, Version 16)
Data class Domain;
Predictors
case c? <Length>=756> and <Length<=1134>
PROSITE; PS51589; SAM_MT56_VP3
end case
Name Viral protein 3 containing mRNA (guanine-N(7))-methyltransferase.
Function mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine.
Scope(s) Viruses
Example(s) Q65526 (VP3_ROTBS);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.56;

Comments [?]

CATALYTIC ACTIVITY Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617; EC=2.1.1.56;

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0004482; Molecular function:mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]