PROSITE

Accession	PRU00930
Dates	14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 7)

Data class

Domain

Predictors

PROSITE; PS51598; SAM_CHO2

Name	Phosphatidylethanolamine N-methyltransferase

Function

Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine.

+ RecName: EC 2.1.1.17;

Catalytic activity	RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.17
Similarity	Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.

GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Lipid biosynthesis
Lipid metabolism
Methyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
S-adenosyl-L-methionine
Transferase

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	A2R616 (CHO2_ASPNC)
Scope	Eukaryota; Dikarya
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB/Swiss-Prot sets

Eukaryota

[61]