ProRule PRU00930
General rule information
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| Accession | PRU00930 |
| Dates | 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
case c? <Length>=725> and <Length<=1087>
PROSITE; PS51598; SAM_CHO2 end case
|
Name | Phosphatidylethanolamine N-methyltransferase |
| Function | Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Dikarya |
| Example(s) | A2R616 (CHO2_ASPNC); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.17; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17; |
| SIMILARITY | Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. |
Keywords
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| Lipid biosynthesis |
| Lipid metabolism |
| Methyltransferase |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| S-adenosyl-L-methionine |
| Transferase |
Gene Ontology
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| GO:0004608; Molecular function:phosphatidylethanolamine N-methyltransferase activity |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [61] All [ 61 ]
- Retrieve set of proteins with 3D structure for this domain