ProRule PRU00933
General rule information
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Accession | PRU00933 |
Dates | 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 9) |
Data class | Domain; |
Predictors |
case c? <Length>=218> and <Length<=328>
PROSITE; PS51601; SAM_NNMT_PNMT_TEMT_3 end case
|
Name | NNMT, PNMT, TEMT and homologues. |
Function | Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. Phenylethanolamine N-methyltransferase (EC 2.1.1.28) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phenylethanolamine to form N-methylphenylethanolamine and S-adenosyl-L homocysteine. Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. Thioether S-methyltransferase (EC 2.1.1.96) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to dimethyl sulfide to form trimethylsulfonium and S-adenosyl-L-homocysteine. |
Scope(s) |
Eukaryota Metazoa |
Example(s) | Q5RFR7 (INMT_PONAB); |
Propagated annotation
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Identifier, protein and gene names
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Protein name | + RecName: EC=2.1.1.-; |
Comments
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SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Keywords
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Gene Ontology
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GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity |
GO:0032259; Biological process:methylation |
GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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From: PS51601 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 74 | 75 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
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BINDING | 152 | 153 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
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BINDING | 35 | 35 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 40 | 40 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 80 | 80 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 96 | 96 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 101 | 101 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
BINDING | 182 | 182 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[AFLT] |
Additional information
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Size range | unlimited amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.