PRU00933
General rule information
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| Accession | PRU00933 |
| Dates | 14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain |
case <Length>=218> and <Length<=328>
| Predictors | PROSITE; PS51601; SAM_NNMT_PNMT_TEMT_3 |
end case
| Name | NNMT, PNMT, TEMT and homologues. |
| Function | Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. Phenylethanolamine N-methyltransferase (EC 2.1.1.28) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phenylethanolamine to form N-methylphenylethanolamine and S-adenosyl-L homocysteine. Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. Thioether S-methyltransferase (EC 2.1.1.96) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to dimethyl sulfide to form trimethylsulfonium and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.-; |
Comments
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| Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Gene Ontology
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GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Features
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| From: PS51601 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 74 | 75 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | |||||||||
| BINDING | 152 | 153 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | |||||||||
| BINDING | 35 | 35 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 40 | 40 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 80 | 80 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 96 | 96 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | ||||||||
| BINDING | 101 | 101 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | N | ||||||||
| BINDING | 182 | 182 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [AFLT] | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q5RFR7 (INMT_PONAB) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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