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annotation rule: PRU00933

General rule information [?]

Accession PRU00933
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
case <Length>=218> and <Length<=328>
Predictors PROSITE; PS51601; SAM_NNMT_PNMT_TEMT_3
end case

Name NNMT, PNMT, TEMT and homologues.
Function Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. Phenylethanolamine N-methyltransferase (EC 2.1.1.28) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phenylethanolamine to form N-methylphenylethanolamine and S-adenosyl-L homocysteine. Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. Thioether S-methyltransferase (EC 2.1.1.96) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to dimethyl sulfide to form trimethylsulfonium and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

Gene Ontology [?]

GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51601
Key     From     To       Description   Tag   Condition   FTGroup
REGION     74     75       S-adenosyl-L-methionine binding        
REGION     152     153       S-adenosyl-L-methionine binding        
BINDING     35     35       S-adenosyl-L-methionine     Y  
BINDING     40     40       S-adenosyl-L-methionine     Y  
BINDING     80     80       S-adenosyl-L-methionine     Y  
BINDING     96     96       S-adenosyl-L-methionine     D  
BINDING     101     101       S-adenosyl-L-methionine     N  
BINDING     182     182       S-adenosyl-L-methionine; via carbonyl oxygen     [AFLT]  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5RFR7 (INMT_PONAB)
Scope
Eukaryota; Metazoa
Comments None

Copyright

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