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ProRule PRU00933


General rule information [?]

Accession PRU00933
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors
case c? <Length>=218> and <Length<=328>
PROSITE; PS51601; SAM_NNMT_PNMT_TEMT_3
end case
Name NNMT, PNMT, TEMT and homologues.
Function Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. Phenylethanolamine N-methyltransferase (EC 2.1.1.28) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phenylethanolamine to form N-methylphenylethanolamine and S-adenosyl-L homocysteine. Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. Thioether S-methyltransferase (EC 2.1.1.96) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to dimethyl sulfide to form trimethylsulfonium and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Metazoa
Example(s) Q5RFR7 (INMT_PONAB);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

Keywords [?]


Gene Ontology [?]

GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51601
Key From To Description Tag Condition FTGroup
BINDING 74 75 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
BINDING 152 153 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
BINDING 35 35 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
Y
BINDING 40 40 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
Y
BINDING 80 80 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
Y
BINDING 96 96 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 101 101 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
N
BINDING 182 182 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[AFLT]

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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