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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00942


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00942
General rule information [?]

Accession PRU00942
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 8)
Data class Domain;
Predictors
case c? <Length>=258> and <Length<=388>
PROSITE; PS51610; SAM_CLNMT
end case
Name Calmodulin-lysine N-methyltransferase
Function Calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to calmodulin L-lysine to form calmodulin N(6)-methyl-L-lysine and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q7Z624;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.60;

Comments [?]

CATALYTIC ACTIVITY Reaction=[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:21556, Rhea:RHEA-COMP:11360, Rhea:RHEA-COMP:11361, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.60;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0018025; Molecular function:calmodulin-lysine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]