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ProRule PRU00942


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00942
Accession PRU00942
Dates 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 7)
Data class Domain;
Predictors
case c? <Length>=258> and <Length<=388>
PROSITE; PS51610; SAM_CLNMT
end case
Name Calmodulin-lysine N-methyltransferase
Function Calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to calmodulin L-lysine to form calmodulin N(6)-methyl-L-lysine and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q7Z624 (CMKMT_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.60;

Comments [?]

CATALYTIC ACTIVITY Reaction=[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:21556, Rhea:RHEA-COMP:11360, Rhea:RHEA-COMP:11361, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.60;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0018025; Molecular function:calmodulin-lysine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]