ProRule PRU00942
General rule information
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| Accession | PRU00942 |
| Dates | 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
case c? <Length>=258> and <Length<=388>
PROSITE; PS51610; SAM_CLNMT end case
|
Name | Calmodulin-lysine N-methyltransferase |
| Function | Calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to calmodulin L-lysine to form calmodulin N(6)-methyl-L-lysine and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q7Z624 (CMKMT_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.60; |
Comments
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| CATALYTIC ACTIVITY | Reaction=[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21556, Rhea:RHEA-COMP:11360, Rhea:RHEA-COMP:11361, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.60; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family. |
Keywords
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Gene Ontology
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| GO:0018025; Molecular function:calmodulin-lysine N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain