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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00943


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PURL: https://purl.expasy.org/prosite/rule/PRU00943
General rule information [?]

Accession PRU00943
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 10)
Data class Domain;
Predictors
case c? <Length>=400> and <Length<=600>
PROSITE; PS51611; SAM_MT59
end case
Name [Cytochrome c]-lysine N-methyltransferase
Function [Cytochrome c]-lysine N-methyltransferase (EC 2.1.1.59) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to [cytochrome c]-L-lysine to form [cytochrome c]-N(6)-methyl-L-lysine and S- adenosyl-L-homocysteine.
Scope(s) Eukaryota
Saccharomycetaceae
Example(s) Q6FR37;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.59;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = N(6)- methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:24312, Rhea:RHEA-COMP:9754, Rhea:RHEA-COMP:9755, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.59;
SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0000277; Molecular function:[cytochrome c]-lysine N-methyltransferase activity

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]