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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00946


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00946
General rule information [?]

Accession PRU00946
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51614; SAM_MT_ADRIFT
Name Adrift-type ribose 2'-O-methyltransferase (EC 2.1.1.-) domain
Function 2'-O-methyltransferase
Scope(s) Viruses
Eukaryota
Metazoa
Example(s) Q5RAY7;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0008168; Molecular function:methyltransferase activity

Features [?]

From: PS51614
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Adrift-type SAM-dependent 2'-O-MTase #"
ACT_SITE 168 168 /note="Proton acceptor" K
BINDING 40 40 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 59 59 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 W
BINDING 128 128 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 D

Additional information [?]

Size range 199-224 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]