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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00947


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PURL: https://purl.expasy.org/prosite/rule/PRU00947
General rule information [?]

Accession PRU00947
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 13)
Data class Domain;
Predictors
case c? <Length>=282> and <Length<=424>
PROSITE; PS51615; SAM_MT_PUTRESCINE
end case
Name Putrescine N-methyltransferase
Function Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to putrescine to form N-methylputrescine and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Magnoliopsida
Example(s) O48659;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.53;

Comments [?]

CATALYTIC ACTIVITY Reaction=putrescine + S-adenosyl-L-methionine = N-methylputrescine + S- adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:15037, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58039, ChEBI:CHEBI:59789, ChEBI:CHEBI:326268; EC=2.1.1.53;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0030750; Molecular function:putrescine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51615
Key From To Description Tag Condition FTGroup
BINDING 201 202 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
ACT_SITE 220 220 /note="Proton acceptor" D
BINDING 95 95 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Q
BINDING 170 170 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 E
BINDING 289 289 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Y

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]