ProRule PRU00947
General rule information
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| Accession | PRU00947 |
| Dates | 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
case c? <Length>=282> and <Length<=424>
PROSITE; PS51615; SAM_MT_PUTRESCINE end case
|
Name | Putrescine N-methyltransferase |
| Function | Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to putrescine to form N-methylputrescine and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Magnoliopsida |
| Example(s) | O48659 (SPDS2_HYONI); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.53; |
Comments
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| CATALYTIC ACTIVITY | Reaction=putrescine + S-adenosyl-L-methionine = H(+) + N- methylputrescine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:15037, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58039, ChEBI:CHEBI:59789, ChEBI:CHEBI:326268; EC=2.1.1.53; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family. |
Keywords
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Gene Ontology
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| GO:0030750; Molecular function:putrescine N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51615 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 201 | 202 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| ACT_SITE | 220 | 220 | /note="Proton acceptor" | D | ||||||||
| BINDING | 95 | 95 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Q | ||||||||
| BINDING | 170 | 170 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
| BINDING | 289 | 289 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain