ProRule PRU00947
General rule information
[?]
| Accession | PRU00947 |
| Dates | 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
case c? <Length>=282> and <Length<=424>
PROSITE; PS51615; SAM_MT_PUTRESCINE end case
|
Name | Putrescine N-methyltransferase |
| Function | Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to putrescine to form N-methylputrescine and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Magnoliopsida |
| Example(s) | O48659 (SPDS2_HYONI); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + RecName: EC=2.1.1.53; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=putrescine + S-adenosyl-L-methionine = N-methylputrescine + S- adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:15037, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58039, ChEBI:CHEBI:59789, ChEBI:CHEBI:326268; EC=2.1.1.53; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0030750; Molecular function:putrescine N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
[?]
| From: PS51615 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 201 | 202 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| ACT_SITE | 220 | 220 | /note="Proton acceptor" | D | ||||||||
| BINDING | 95 | 95 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Q | ||||||||
| BINDING | 170 | 170 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
| BINDING | 289 | 289 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
Additional information
[?]
| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain