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ProRule PRU00947


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PURL: https://purl.expasy.org/prosite/rule/PRU00947
General rule information [?]

Accession PRU00947
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version )
Data class Domain;
Predictors
case c? <Length>=282> and <Length<=424>
PROSITE; PS51615; SAM_MT_PUTRESCINE
end case
Name Putrescine N-methyltransferase
Function Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to putrescine to form N-methylputrescine and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Magnoliopsida
Example(s) O48659;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.53;

Comments [?]

CATALYTIC ACTIVITY Reaction=putrescine + S-adenosyl-L-methionine = N-methylputrescine + S- adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:15037, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58039, ChEBI:CHEBI:59789, ChEBI:CHEBI:326268; EC=2.1.1.53;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0030750; Molecular function:putrescine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51615
Key From To Description Tag Condition FTGroup
BINDING 201 202 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
ACT_SITE 220 220 /note="Proton acceptor" D
BINDING 95 95 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Q
BINDING 170 170 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 E
BINDING 289 289 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Y

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]