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annotation rule: PRU00947

General rule information [?]

Accession PRU00947
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
case <Length>=282> and <Length<=424>
Predictors PROSITE; PS51615; SAM_MT_PUTRESCINE
end case

Name Putrescine N-methyltransferase
Function Putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to putrescine to form N-methylputrescine and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.53;

Comments [?]

Catalytic activity RHEA:15037: putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine
EC 2.1.1.53
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Spermidine/spermine synthase family.

Gene Ontology [?]

GO:0030750; Molecular function: putrescine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51615
Key     From     To       Description   Tag   Condition   FTGroup
REGION     201     202       S-adenosyl-L-methionine binding        
ACT_SITE     220     220       Proton acceptor     D  
BINDING     95     95       S-adenosyl-L-methionine     Q  
BINDING     170     170       S-adenosyl-L-methionine     E  
BINDING     289     289       S-adenosyl-L-methionine     Y  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example O48659 (SPDS2_HYONI)
Scope
Eukaryota; Magnoliopsida
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [4]