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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00959


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00959
General rule information [?]

Accession PRU00959
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors
case c? <OC:Eukaryota> and <Length>=429> and <Length<=643>
PROSITE; PS51627; SAM_MT_TRM11
end case
Name tRNA (guanine(10)-N2)-methyltransferase (EC 2.1.1.214) (TRM11)
Function tRNA (guanine(10)-N(2))-methyltransferase (EC 2.1.1.214) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to guanine(10) in tRNA to form N(2)-methylguanine(10) in tRNA and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Example(s) O94636;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0000049; Molecular function:tRNA binding
GO:0016423; Molecular function:tRNA (guanine) methyltransferase activity
GO:0008033; Biological process:tRNA processing
GO:0032259; Biological process:methylation

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]