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ProRule PRU00965


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PURL: https://purl.expasy.org/prosite/rule/PRU00965
General rule information [?]

Accession PRU00965
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51270; ZF_CTCHY
Name Zinc finger CTCHY-type
Function The CTCHY-type zinc finger is required for binding to p53 in mammals.
Scope(s) Eukaryota
Example(s) Q96PM5 (ZN363_HUMAN);

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS51270:6=[CH]> and <Feature:PS51270:9=[CH]> and <Feature:PS51270:22=[CH]> and <Feature:PS51270:29=[CH]>) or (<Feature:PS51270:23=[CH]> and <Feature:PS51270:26=[CH]> and <Feature:PS51270:39=[CH]> and <Feature:PS51270:46=[CH]>) or (<Feature:PS51270:40=[CH]> and <Feature:PS51270:43=[CH]> and <Feature:PS51270:55=[CH]> and <Feature:PS51270:57=[CH]>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51270
Key From To Description Tag Condition FTGroup
case <Feature:PS51270:6=[C]> and <Feature:PS51270:9=[C]> and <Feature:PS51270:22=[H]> and <Feature:PS51270:29=[C]> and <Feature:PS51270:23=[C]> and <Feature:PS51270:26=[C]> and <Feature:PS51270:39=[H]> and <Feature:PS51270:46=[C]> and <Feature:PS51270:40=[C]> and <Feature:PS51270:43=[C]> and <Feature:PS51270:55=[H]> and <Feature:PS51270:57=[C]>
ZN_FING from to /note="CTCHY-type #"
else case <Feature:PS51270:6=[CH]> and <Feature:PS51270:9=[CH]> and <Feature:PS51270:22=[CH]> and <Feature:PS51270:29=[CH]> and <Feature:PS51270:23=[CH]> and <Feature:PS51270:26=[CH]> and <Feature:PS51270:39=[CH]> and <Feature:PS51270:46=[CH]> and <Feature:PS51270:40=[CH]> and <Feature:PS51270:43=[CH]> and <Feature:PS51270:55=[CH]> and <Feature:PS51270:57=[CH]>
ZN_FING from to /note="CTCHY-type #; atypical"
else
ZN_FING from to /note="CTCHY-type #; degenerate"
end case
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 39 39 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 43 43 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 46 46 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 57 57 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3

Additional information [?]

Size range 53-77 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]