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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00965


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00965
General rule information [?]

Accession PRU00965
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51270; ZF_CTCHY
Name Zinc finger CTCHY-type
Function The CTCHY-type zinc finger is required for binding to p53 in mammals.
Scope(s) Eukaryota
Example(s) Q96PM5;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS51270:6=[CH]> and <Feature:PS51270:9=[CH]> and <Feature:PS51270:22=[CH]> and <Feature:PS51270:29=[CH]>) or (<Feature:PS51270:23=[CH]> and <Feature:PS51270:26=[CH]> and <Feature:PS51270:39=[CH]> and <Feature:PS51270:46=[CH]>) or (<Feature:PS51270:40=[CH]> and <Feature:PS51270:43=[CH]> and <Feature:PS51270:55=[CH]> and <Feature:PS51270:57=[CH]>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51270
Key From To Description Tag Condition FTGroup
case <Feature:PS51270:6=[C]> and <Feature:PS51270:9=[C]> and <Feature:PS51270:22=[H]> and <Feature:PS51270:29=[C]> and <Feature:PS51270:23=[C]> and <Feature:PS51270:26=[C]> and <Feature:PS51270:39=[H]> and <Feature:PS51270:46=[C]> and <Feature:PS51270:40=[C]> and <Feature:PS51270:43=[C]> and <Feature:PS51270:55=[H]> and <Feature:PS51270:57=[C]>
ZN_FING from to /note="CTCHY-type #"
else case <Feature:PS51270:6=[CH]> and <Feature:PS51270:9=[CH]> and <Feature:PS51270:22=[CH]> and <Feature:PS51270:29=[CH]> and <Feature:PS51270:23=[CH]> and <Feature:PS51270:26=[CH]> and <Feature:PS51270:39=[CH]> and <Feature:PS51270:46=[CH]> and <Feature:PS51270:40=[CH]> and <Feature:PS51270:43=[CH]> and <Feature:PS51270:55=[CH]> and <Feature:PS51270:57=[CH]>
ZN_FING from to /note="CTCHY-type #; atypical"
else
ZN_FING from to /note="CTCHY-type #; degenerate"
end case
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 39 39 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 43 43 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 46 46 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 57 57 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3

Additional information [?]

Size range 53-77 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]