ProRule PRU00966
General rule information
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| Accession | PRU00966 |
| Dates | 22-DEC-2011 (Created)
27-JUN-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51152; NFYA_HAP2_2 |
Name | NF-YA/HAP2 family |
| Function | The CCAAT-binding factor (CBF) or NF-Y is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The second subunit of CBF, known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast, contains a highly conserved region of about 60 residues. This region, called the 'essential core', seems to consist of two subdomains: an N-terminal subunit-association domain and a C-t erminal DNA recognition domain. |
| Scope(s) |
Eukaryota |
| Example(s) | P24488 (HAP2_SCHPO); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the NFYA/HAP2 subunit family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0006351; Biological process:DNA-templated transcription |
| GO:0003700; Molecular function:DNA-binding transcription factor activity |
| GO:0016602; Cellular component:CCAAT-binding factor complex |
| GO:0005634; Cellular component:nucleus |
Cross-references
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| PROSITE | PS00686; NFYA_HAP2_1; 1; |
Features
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| From: PS51152 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 36 | 61 | /note="NFYA/HAP2-type #" | |||||||||
| MOTIF | 6 | 29 | /note="Subunit association domain (SAD) #" | |||||||||
Additional information
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| Size range | 48-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain