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ProRule PRU00966


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PURL: https://purl.expasy.org/prosite/rule/PRU00966
General rule information [?]

Accession PRU00966
Dates 22-DEC-2011 (Created)
27-JUN-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51152; NFYA_HAP2_2
Name NF-YA/HAP2 family
Function The CCAAT-binding factor (CBF) or NF-Y is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The second subunit of CBF, known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast, contains a highly conserved region of about 60 residues. This region, called the 'essential core', seems to consist of two subdomains: an N-terminal subunit-association domain and a C-t erminal DNA recognition domain.
Scope(s) Eukaryota
Example(s) P24488;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the NFYA/HAP2 subunit family.

Keywords [?]

Activator
DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006351; Biological process:DNA-templated transcription
GO:0003700; Molecular function:DNA-binding transcription factor activity
GO:0016602; Cellular component:CCAAT-binding factor complex
GO:0005634; Cellular component:nucleus

Cross-references [?]

PROSITE PS00686; NFYA_HAP2_1; 1;

Features [?]

From: PS51152
Key From To Description Tag Condition FTGroup
DNA_BIND 36 61 /note="NFYA/HAP2-type #"
MOTIF 6 29 /note="Subunit association domain (SAD) #"

Additional information [?]

Size range 48-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]