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annotation rule: PRU00966

General rule information [?]

Accession PRU00966
Dates 22-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51152; NFYA_HAP2_2
Name NF-YA/HAP2 family
Function The CCAAT-binding factor (CBF) or NF-Y is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The second subunit of CBF, known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast, contains a highly conserved region of about 60 residues. This region, called the 'essential core', seems to consist of two subdomains: an N-terminal subunit-association domain and a C-t erminal DNA recognition domain.

Propagated annotation [?]

Comments [?]

Subcellular location Nucleus.
Similarity Belongs to the NFYA/HAP2 subunit family.

Cross-references [?]

PROSITE PS00686; NFYA_HAP2_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006351; Biological process: transcription, DNA-templated.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0016602; Cellular component: CCAAT-binding factor complex.
GO:0005634; Cellular component: nucleus.

Keywords [?]

Features [?]

From: PS51152
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     36     61       NFYA/HAP2-type #        
MOTIF     6     29       Subunit association domain (SAD) #        

Additional information [?]

Size range 48-75 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P24488 (HAP2_SCHPO)
Comments None


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UniProtKB rule member sequences [?]