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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00966


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00966
General rule information [?]

Accession PRU00966
Dates 22-DEC-2011 (Created)
27-JUN-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51152; NFYA_HAP2_2
Name NF-YA/HAP2 family
Function The CCAAT-binding factor (CBF) or NF-Y is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The second subunit of CBF, known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast, contains a highly conserved region of about 60 residues. This region, called the 'essential core', seems to consist of two subdomains: an N-terminal subunit-association domain and a C-t erminal DNA recognition domain.
Scope(s) Eukaryota
Example(s) P24488;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the NFYA/HAP2 subunit family.

Keywords [?]

Activator
DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006351; Biological process:DNA-templated transcription
GO:0003700; Molecular function:DNA-binding transcription factor activity
GO:0016602; Cellular component:CCAAT-binding factor complex
GO:0005634; Cellular component:nucleus

Cross-references [?]

PROSITE PS00686; NFYA_HAP2_1; 1;

Features [?]

From: PS51152
Key From To Description Tag Condition FTGroup
DNA_BIND 36 61 /note="NFYA/HAP2-type #"
MOTIF 6 29 /note="Subunit association domain (SAD) #"

Additional information [?]

Size range 48-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]