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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00968


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00968
General rule information [?]

Accession PRU00968
Dates 06-JAN-2012 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51002; CYTB_NTER
Name Cytochrome b/b6 N-terminal region
Function The cytochrome b/b6 are transmembrane proteins containing to protohemes responsible for vectorial electron transfer.
Scope(s) Eukaryota
Bacteria
Example(s) P00163;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the cytochrome b family.

Keywords [?]

Heme
Iron
Metal-binding
end case
Membrane
Transmembrane
Transmembrane helix
Transport
Electron transport

Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity
GO:0016020; Cellular component:membrane
GO:0006810; Biological process:transport
GO:0022900; Biological process:electron transport chain
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

General Transmembrane; -; 5;

Features [?]

From: PS51002
Key From To Description Tag Condition FTGroup
TRANSMEM 33 53 /note="Helical"
TRANSMEM 86 106 /note="Helical"
TRANSMEM 117 137 /note="Helical"
TRANSMEM 152 172 /note="Helical"
TRANSMEM 180 201 /note="Helical"
case <AnyFeature:PS51003>
BINDING 83 83 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="b562"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 97 97 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="b566"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 184 184 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="b562"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 199 199 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="b566"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
else
BINDING 83 83 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_label="2"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 97 97 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 184 184 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_label="2"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 199 199 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
end case

Additional information [?]

Size range 167-239 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]