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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00969


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00969
General rule information [?]

Accession PRU00969
Dates 15-SEP-2014 (Created)
08-OCT-2024 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS50979; BC
Name Biotin carboxylation domain
Function The biotin carboxylation domain is common to all biotin-dependent carboxylases and mediates the carboxylation of enzyme-bound biotin by bicarbonate and ATP. The biotin carboxylation domain can be divided in three subdomains (N-terminal, central and C-terminal). The N-terminal region provides part of the active site; the central region corresponds to the ATP- grasp domain, which is common to many ATP-dependent enzymes involved in macromolecular synthesis. The ATP-grasp module directly binds the ATP molecule. The C-terminal subdomain is involved in dimer formation.
Scope(s) Eukaryota
Bacteria
Archaea
Methanobacteriati
Example(s) Q9UUE1;

Propagated annotation [?]

Keywords [?]

Ligase
Biotin

Gene Ontology [?]

GO:0004075; Molecular function:biotin carboxylase activity

Cross-references [?]

PROSITE PS50975; ATP_GRASP; 1;

Features [?]

From: PS50979
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Biotin carboxylation #"

Additional information [?]

Size range 19-520 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]