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annotation rule: PRU00969

General rule information [?]

Accession PRU00969
Dates 15-SEP-2014 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS50979; BC
Name Biotin carboxylation domain
Function The biotin carboxylation domain is common to all biotin-dependent carboxylases and mediates the carboxylation of enzyme-bound biotin by bicarbonate and ATP. The biotin carboxylation domain can be divided in three subdomains (N-terminal, central and C-terminal). The N-terminal region provides part of the active site; the central region corresponds to the ATP- grasp domain, which is common to many ATP-dependent enzymes involved in macromolecular synthesis. The ATP-grasp module directly binds the ATP molecule. The C-terminal subdomain is involved in dimer formation.

Propagated annotation [?]

Cross-references [?]

PROSITE PS50975; ATP_GRASP; 1; trigger=PRU00409;

Gene Ontology [?]

GO:0004075; Molecular function: biotin carboxylase activity.

Keywords [?]

Features [?]

From: PS50979
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Biotin carboxylation #        

Additional information [?]

Size range 19-520 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9UUE1 (PYC_SCHPO)
Archaea; Euryarchaeota
Comments None


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UniProtKB rule member sequences [?]