ProRule PRU00969
General rule information
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| Accession | PRU00969 |
| Dates | 15-SEP-2014 (Created)
8-OCT-2024 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50979; BC |
Name | Biotin carboxylation domain |
| Function | The biotin carboxylation domain is common to all biotin-dependent carboxylases and mediates the carboxylation of enzyme-bound biotin by bicarbonate and ATP. The biotin carboxylation domain can be divided in three subdomains (N-terminal, central and C-terminal). The N-terminal region provides part of the active site; the central region corresponds to the ATP- grasp domain, which is common to many ATP-dependent enzymes involved in macromolecular synthesis. The ATP-grasp module directly binds the ATP molecule. The C-terminal subdomain is involved in dimer formation. |
| Scope(s) |
Eukaryota Bacteria Archaea Methanobacteriati |
| Example(s) | Q9UUE1 (PYC_SCHPO); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0004075; Molecular function:biotin carboxylase activity |
Cross-references
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| PROSITE | PS50975; ATP_GRASP; 1; |
Features
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| From: PS50979 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Biotin carboxylation #" | |||||||||
Additional information
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| Size range | 19-520 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [4] Bacteria [19] Eukaryota [54] All [ 77 ]
- Retrieve set of proteins with 3D structure for this domain