We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00977
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00977
General rule information
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| Accession | PRU00977 |
| Dates | 21-JUN-2012 (Created)
08-OCT-2024 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50164; GIY_YIG |
Name | GIY-YIG domain |
| Function | The GIY-YIG superfamily groups together nucleases characterized by the presence of a domain of typically ~100 amino acids, with two short motifs "GIY" and "YIG" in the N-terminal part, followed by an Arg residue in the center and a Glu residue in the C-terminal part. |
| Scope(s) |
Bacteria Eukaryota Archaea Methanobacteriati Viruses |
| Example(s) | B4TYW7; |
Propagated annotation
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Gene Ontology
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| GO:0090304; Biological process:nucleic acid metabolic process |
Features
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| From: PS50164 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GIY-YIG #" | |||||||||
Additional information
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| Size range | 64-129 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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