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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00979


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00979
General rule information [?]

Accession PRU00979
Dates 12-OCT-2012 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51647; CYSTATIN_KININOGEN
Name Kininogen-type cystatin domain
Function Kininogens are multifunctional and multidomain glycoproteins related to cystatins.
Scope(s) Eukaryota
Eutheria
Example(s) P08934;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
Protease inhibitor
Thiol protease inhibitor

Gene Ontology [?]

GO:0004869; Molecular function:cysteine-type endopeptidase inhibitor activity
GO:0010466; Biological process:negative regulation of peptidase activity

Features [?]

From: PS51647
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Cystatin kininogen-type #"
DISULFID 56 67 disulf C-x*-C
DISULFID 56 69 disulf C-x*-C
DISULFID 80 99 disulf C-x*-C

Additional information [?]

Size range 94-115 amino acids
Related rules None
Fusion None
Repeats 3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]